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Tocopherol Behavior and Membrane Constituents in Erythrocytes with Oxidant Stress

  • Masayuki Miki
  • Tadashi Motoyama
  • Yoshito Takenaka
  • Makoto Mino
Part of the Basic Life Sciences book series (BLSC, volume 49)

Abstract

Recently, toxicity caused by oxygen and its active species has received much attention in connection with a variety of pathological events.1 However, the mechanism responsible for the peroxidation of biomembranes is still unclear. Tocopherols (vitamin E) are located in the membranes and act there as an only chain-breaking antioxidant.2,3 When biomembranes are damaged mainly by a free radical chain oxidation,4 the effects of tocopherols will be spotlighted. Nevertheless, the mechanisms by which membrane tocopherols inhibit the peroxidation still require detailed study, partly because the active species and the sites of their generation have not usually been known or controlled.

Keywords

Methyl Linoleate Peroxyl Radical Membrane Constituent Synergistic Inhibition Electron Spin Reso 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Masayuki Miki
    • 1
  • Tadashi Motoyama
    • 1
  • Yoshito Takenaka
    • 1
  • Makoto Mino
    • 1
  1. 1.Department of PediatricsOsaka Medical CollegeTakatsuki, Osaka 569Japan

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