A Secondary Antioxidant Defense Role for Proteolytic Systems

  • Kelvin J. A. Davies
Part of the Basic Life Sciences book series (BLSC, volume 49)


Free radicals, and related oxidants, have long been studied as agents of tissue damage. Lipid peroxidation is a well-established example of free radical toxicity, as is oxidative damage to RNA, DNA, and even carbohydrates. In contrast, the reactions of proteins with various radicals/oxidants have not been so extensively studied and it is sometimes assumed that proteins are not particularly susceptible to free radical damage. This assumption has been invalidated in recent years, and it is now clear that amino acids, peptides, and proteins are, indeed, vulnerable to attack by a variety of free radicals and related oxidants.1–19 Although mechanisms of damage may vary greatly, it appears that oxidative processes are the common pathway for toxic reactions between both free radicals and proteins and various oxidants and proteins. I shall, therefore, use the term “oxidatively damaged proteins” to cover a wide variety of possibilities.


Uric Acid Antioxidant Defense Glutamine Synthetase Cyanogen Bromide Proteolytic System 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Kelvin J. A. Davies
    • 1
  1. 1.Institute for Toxicology and Department of BiochemistryThe University of Southern CaliforniaLos AngelesUSA

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