Reactive Oxygen Metabolites and Hyperoxic Toxicity
Reactive oxygen species are implicated in the pathology of an ever- increasing number of conditions, including post-ischemic damage, inflammation, cancer, drug action, radiation and ageing. Hyperoxic damage to cells is also considered to be caused by production of reactive oxygen metabolites at rates which exceed the detoxifying capacities of the cells’ antioxidant defense mechanisms. In this article I shall briefly review the current evidence for the role of reactive oxygen species in oxygen toxicity, with particular emphasis on the two main target organs for hyperoxic damage in mammals, namely, lung and brain.
KeywordsHyperbaric Oxygen H202 Production Oxygen Toxicity Pyridine Nucleotide Reactive Oxygen Metabolite
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