Cytochrome P-448 Induction Restores the Propagation of •O2--Induced Lipid Peroxidation in Hepatoma Microsomes
It is well established that intracellular and plasma membranes of cancer cells are resistant to lipid peroxidation and that such resistance is related directly to the growth rate and inversely to the degree of differentiation of the tumor.1 Lipid peroxidation byproducts are capable of inhibiting the mitotic activity of normal and tumor cells, 2,3 supporting the early hypothesis that the low peroxidizability of tumor membranes may be one of the factors responsible for the increased proliferative activity of malignant cells.4,5 Consistently, a reasonable approach to the study of lipid peroxidation in tumors is that of establishing the factors which limit the process and possibly finding strategies for restoring it at levels comparable to those of normal cells. The present and previous studies performed in our laboratory are aimed at carrying out this project.
KeywordsLipid Peroxidation Xanthine Oxidase Ehrlich Ascites Tumor Cell Ehrlich Ascites Tumor Italian National Research Council
Unable to display preview. Download preview PDF.
- 2.D. G. Cornwell and N. Marisaki, Fatty acids paradoxes in the control of cell proliferation: prostaglandins, lipid peroxides and cooxidation reactions, in: “Free Radicals in Biology,” Vol. 6, W. A. Pryor, ed., Academic Press, New York (1984).Google Scholar
- 3.S. Hauptlorenz, H. Esterbauer, W. Moll, R. Pumpel, E. Schauenstein, and B. Puschendorf, Effects of the lipid peroxidation product 4-hydroxy-nonenal and related aldehydes on proliferation and viability of cultured Ehrlich Ascites tumor cells, Biochem. Pharmacol. 34:3803 (1985).PubMedCrossRefGoogle Scholar
- 5.T. Galeotti, G. M. Bartoli, S. Bartoli, and E. Bertoli, Superoxide radicals and lipid peroxidation in tumour microsomal membranes, in: “Biological and Clinical Aspects of Superoxide and Superoxide Dismutase,” W. H. Bannister and J. V. Bannister, eds., Elsevier, Amsterdam (1980).Google Scholar
- 6.H. P. Morris and B. P. Wagner, Induction and transplantation of rat hepatomas with different growth rate (including “minimal deviation” hepatomas), in.: “Methods in Cancer Research,” Vol. 4, H. Busch, ed., Academic Press, New York (1968).Google Scholar