Cytochrome P-448 Induction Restores the Propagation of •O2--Induced Lipid Peroxidation in Hepatoma Microsomes

  • Tommaso Galeotti
  • Silvia Borrello
Part of the Basic Life Sciences book series (BLSC, volume 49)


It is well established that intracellular and plasma membranes of cancer cells are resistant to lipid peroxidation and that such resistance is related directly to the growth rate and inversely to the degree of differentiation of the tumor.1 Lipid peroxidation byproducts are capable of inhibiting the mitotic activity of normal and tumor cells, 2,3 supporting the early hypothesis that the low peroxidizability of tumor membranes may be one of the factors responsible for the increased proliferative activity of malignant cells.4,5 Consistently, a reasonable approach to the study of lipid peroxidation in tumors is that of establishing the factors which limit the process and possibly finding strategies for restoring it at levels comparable to those of normal cells. The present and previous studies performed in our laboratory are aimed at carrying out this project.


Lipid Peroxidation Xanthine Oxidase Ehrlich Ascites Tumor Cell Ehrlich Ascites Tumor Italian National Research Council 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Tommaso Galeotti
    • 1
  • Silvia Borrello
    • 1
  1. 1.Institute of General PathologyCatholic UniversityRomeItaly

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