Cytochrome P-450 Model Systems: Alkene Oxidation
Iron(III) porphyrins efficiently catalyze the epoxidation of alkenes and the hydroxylation of alkanes by iodosylbenzenes and peracids, most likely by the same mechanisms utilized by cytochrome P-450 enzymes. The synthetic catalysts mimic the enzymes in product stereospecificity, 1 the accompanying rearrangements, 2 and the suicide labelling which results in N-alkylhemin formation.3
KeywordsIron Porphyrin Porphyrin Cation Asymmetric Epoxidation Catalytic Epoxidation Oxygen Atom Transfer
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