Substituted Phthalocyanines as Photodynamic Sensitizers
The phthalocyanine dyes have recently been suggested for use in the photodynamic therapy of cancer.1,2 Their superior attributes, such as the very intense light absorption in the wavelength range preferred for photodynamic therapy (600–700 nm), the lack of toxicity and selective localization of some dyes of this group in experimental tumors, the high efficiency to photosensitize killing of mammalian cells in culture, and finally the ability to induce necroses of transplanted tumors in animals3,4 have made this suggestion very attractive.
KeywordsSinglet Oxygen Photodynamic Therapy Nitroxide Radical Chinese Hamster Cell Zinc Phthalocyanine
Unable to display preview. Download preview PDF.
- 1.E. Ben Hur and I. Rosenthal, The phthalocyanines: Synthetic porphyrin-like dyes with improved potential for cancer phototherapy, abstracts, 3rd Annual Meeting of European Society for Therapeutic Radiology and Oncology, Jerusalem, Israel, 1984.Google Scholar
- 9.I. Rosenthal, E. Ben Hur, S. Greenberg, A. Conception-Lam, D.M. Drew, and C.C. Leznoff, The effect of substituents on phthalocyanine photocytotoxicity, Photochem. Photobiol., in press.Google Scholar
- 11.I.G. Farbenindustrie, British Patent 487, 261.Google Scholar