The Uniqueness Both of Superoxide Toxicity and of the Protective Role of Superoxide Dismutase

  • Gidon Czapski
  • Sara Goldstein
Part of the Basic Life Sciences book series (BLSC, volume 49)


The role of superoxide radical (·O 2 - ) in biological processes was established after Fridovich.and McCord discovered the enzyme copper-zinc superoxide dismutase (SOD),1 which catalyzes superoxide dismutation very efficiently. Later, enzymes with similar catalytic activity containing iron and manganese at the active site were discovered.


Superoxide Radical Pulse Radiolysis Copper Compound Catalytic Rate Constant Similar Catalytic Activity 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    J. M. McCord and I. Fridovich, Superoxide dismutase: An enzyme function for erythocuprein, J. Biol, Chem. 244:6049 (1969).Google Scholar
  2. 2.
    S. Goldstein and G. Czapski, The role of metal ions and their complxes in enhancing damage in biological systems or in protecting these systems from the toxicity of O2, J. Free Rad, Biol. Med. 2:3 (1986).CrossRefGoogle Scholar
  3. 3.
    I. Fridovich and J. A. Fee in: “Oxygen and Oxy-Radicals in Chemistry and Biology,” M. A. Rodgers and E. L. Powers, eds, Academic Press, (1981).Google Scholar
  4. 4.
    R. C. Lynch and I. Fridovich, Autoinactivation of xanthine oxidase. The role of superoxide radical and hydrogen peroxide, Biochim. Biophys. Acta 571:195 (1979).PubMedCrossRefGoogle Scholar
  5. 5.
    G. Czapski and Y. Ilan, On the generation of of the hydroxyl agent from superoxide radical: can the Haber-Weiss reaction be the source of OH radicals? Photochem. Photobiol. 28:651 (1978).CrossRefGoogle Scholar
  6. 6.
    S. Goldstein and G. Czapski, Mechanism of the reactions of some copper complexes in the presence of DNA with O2 -, H2O2 and molecular oxygen, J. Am. Chem. Soc. 108:2234 (1986).CrossRefGoogle Scholar
  7. 7.
    D. Klug-Roth, I. Fridovich and J. Rabani, Pulse radiolytic investigation of superoxde catalyzed dispropornation. Mechanism for bovine superoxide dismutase, J. Am. Chem. Soc. 95:2786 (1973).PubMedCrossRefGoogle Scholar
  8. 8.
    J. Weinstein and B. H. J. Bielski, Reaction of superoxide radical with copper(II)-histidine complexes, J. Am. Chem. Soc. 102:4916 (1980).CrossRefGoogle Scholar
  9. 9.
    S. Goldstein and G. Czapski, Kinetic of oxidation of cuprous complexes of substituted phenanthroline and 2,2’-bipyridyl by molecular oxygen and by hydrogen peroxide in aqueous solution, Inorg. Chem. 24:1087 (1985).CrossRefGoogle Scholar
  10. 10.
    R. Brigelius, R. Spottl, W. Bors, E. Lengfelder, M. Saran and U. Weser, SOD actvity of low molecular weight Cu2+ -chelates studied by pulse radiolysis, FEBS Lett. 47:72 (1974).PubMedCrossRefGoogle Scholar
  11. 11.
    A. Zuberbuhler, Helv. Chim. Acta 53:473,669 (1970).PubMedCrossRefGoogle Scholar
  12. 12.
    A. Samuni, J. Aronovich, D. Godinger, M. Chevion and G. Czapski, On the cytotoxicity of vitamin C and metal ions. A site specific mechanism, Eur. J. Biochem. 137:119 (1983).PubMedCrossRefGoogle Scholar
  13. 13.
    M. Anbar and A. Levitzki, Copper-induced radiolytic deactivation of a-amylase and catalas, Radiat. Res. 27:32 (1966).CrossRefGoogle Scholar
  14. 14.
    J. S. Rybka, J. L. Kartz, T. A. Neubecker and D. W. Margerum, Reactions of copper(III) tetraglycine, Inorg. Chem. 19:2791 (1980).CrossRefGoogle Scholar
  15. 15.
    S. Goldstein and G. Czapski, Mechanism of reduction of bleomycin-Cu(II) by CO2 - and oxidation of bleomycin-Cu(I) by H2O2 in the absence and presence of DNA, Int. J. Rad. Biol. 51:259 (1987).CrossRefGoogle Scholar
  16. 16.
    J. D. Rush and W. H. Koppenol, The reaction between ferrous polyamino-carboxylate complexes and hydrogen peroxide: an investigation of the reaction intermediates by stopped flow spectrophotometry, J. Inorg. Biochem. 29:199 (1987).PubMedCrossRefGoogle Scholar
  17. 17.
    B. Halliwell, Manganese ions, oxidation reactions and the superoxide radical, NeuroToxicology 5:113 (1984).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Gidon Czapski
    • 1
  • Sara Goldstein
    • 1
  1. 1.Department of Physical ChemistryThe Hebrew University of JerusalemJerusalemIsrael

Personalised recommendations