The Uniqueness Both of Superoxide Toxicity and of the Protective Role of Superoxide Dismutase
The role of superoxide radical (·O 2 - ) in biological processes was established after Fridovich.and McCord discovered the enzyme copper-zinc superoxide dismutase (SOD),1 which catalyzes superoxide dismutation very efficiently. Later, enzymes with similar catalytic activity containing iron and manganese at the active site were discovered.
KeywordsSuperoxide Radical Pulse Radiolysis Copper Compound Catalytic Rate Constant Similar Catalytic Activity
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- 1.J. M. McCord and I. Fridovich, Superoxide dismutase: An enzyme function for erythocuprein, J. Biol, Chem. 244:6049 (1969).Google Scholar
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