Copper and Copper-Nicotinic Acid Complexes Mediated Oxidation of High Density Lipoprotein
Plasma high density lipoprotein (HDL)-cholesterol and/or apo A-I levels appear to be inversely related to the occurrence of acute myocardial infarctions and have an impact on the onset and progress of atherosclerosis.1,2 Since the outer surface of the high density lipoprotein particle has a low cholesterol/phosphatidylcholine ratio in comparison to most of the cell membranes,3 it is suggested to be an effective acceptor for the transport of cholesterol to various tissues. HDL facilitates the removal of the peripheral tissue cholesterol and delivers it within the “reverse cholesterol transport” to the liver.4 A recent investigation5 on the scavenger function of sinusoidal liver cells showed that chemically acetylated HDL underwent receptor-mediated endocytosis through a pathway distinct from acetylated low-density lipoprotein (LDL) or formaldehyde-treated serum albumin, which suggests the presence of a scavenger receptor for acetylated HDL.
KeywordsHigh Density Lipoprotein Nicotinic Acid Reverse Cholesterol Transport Isonicotinic Acid High Density Lipoprotein Particle
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