Is Oxidized Low Density Lipoprotein Involved in the Recruitment and Retention of Monocyte/Macrophages in the Artery Wall during the Initiation of Atherosclerosis?
Atheroma or atherosclerosis is a disease affecting major arteries, wherein the intimai layer of the artery is engorged with both intracellular and extracellular lipids, mostly cholesterol esters. Cholesterol, particularly that associated with low density lipoproteins (LDL), has been identified as a major risk factor. The precise mechanism(s) by which LDL cholesterol becomes atherogenic has not been well understood.
KeywordsFoam Cell Chemotactic Activity WHHL Rabbit Cholesteryl Linoleate Cholesteryl Ester Accumulation
Unable to display preview. Download preview PDF.
- 5.T. Henriksen, E.M. Mahoney and D. Steinberg, Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by the receptor for acetylated low density lipoproteins, Proc. Natl. Acad. Sci. U.S.A. 78:6499 (1981).PubMedCrossRefGoogle Scholar
- 7.U.P. Steinbrecher, S. Parthasarathy, D.S. Leake, J.L. Witztum, and D. Steinberg, Modification of low density lipoprotein by endothelial cell involves lipid peroxidation and degradation of low density lipoprotein phospholipids, Proc. Natl. Acad. Sci. U.S.A. 81:3883 (1984).PubMedCrossRefGoogle Scholar
- 15.T. Kita, Y. Nagano, M. Yokode, K. Ishii, N. Kume, A. Ooshima, H. Yoshida, and C. Kawai, Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia, Proc. Natl. Acad. Sci. U.S.A 84:5928 (1987).PubMedCrossRefGoogle Scholar
- 16.T.E. Carew, D.C. Schwenke, and D. Steinberg, An antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: Evidence that antioxidants in vivo can inhibit low density lipoprotein degradation in macrophage rich fatty streaks and slow the progression of atherosclerosis in the WHHL rabbit, Proc. Natl. Acad. Sci. U.S.A., 84:7725 (1987).PubMedCrossRefGoogle Scholar
- 17.R.W. Mahley, Alterations in plasma lipoproteins induced by cholesterol feeding in animals including man, in: “Disturbances in Lipid and Lipoprotein metabolism,” Dietschy, et al., eds., Am. Physiol. Soc. Bethesda, MD. (1978).Google Scholar
- 19.S. Suylok, Bar-Pollak, E. Feher, I. Kemenes, I. Kantor, and J. Feher, Liver lipid peroxidation induced by cholesterol and its treatment with a dihydroquinoline type free radical scavenger in rabbits, Acta Physiol. Hung.. 64:437 (1984).Google Scholar