A Study of ROS Induced Denaturation of IgG3 Using Monoclonal Antibodies; Implications for Inflammatory Joint Disease

  • H. R. Griffiths
  • J. Lunec
  • R. Jefferis
  • D. R. Blake
  • R. L. Willson
Part of the Basic Life Sciences book series (BLSC, volume 49)


Inflammatory joint disease is characterised by an infiltration of phagocytes into articular spaces. When these cells are activated by immune complexes, bacteria or components of the complement cascade, the release proteases and the reactive oxygen species (ROS) •O- 2 and H2O2.1 Whilst the stimulus for phagocytic infiltration and activation remains unknown, it has been shown that the ROS released have the capacity to further damage cartilage,2 synovial fluid3 and IgG.4 The latter is of particular interest since it is believed that production of autoantibodies to a conformationally altered IgG molecule may perpetuate the inflammatory response and promote disease chronicity.5


Reactive Oxygen Species Synovial Fluid Hinge Region Serial Twofold Dilution Inflammatory Joint Disease 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • H. R. Griffiths
    • 1
  • J. Lunec
    • 1
  • R. Jefferis
    • 2
  • D. R. Blake
    • 1
  • R. L. Willson
    • 3
  1. 1.Departments of Biochemistry and RheumatologyShelly Oak HospitalBirminghamUK
  2. 2.Department of ImmunologyUniversity of BirminghamBirminghamUK
  3. 3.Department of BiochemistryBrunei UniversityLondonUK

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