Free Radical Denaturation of Immunoglobulin G is due to Amino Acid Oxidation: Implications for Rheumatoid Arthritis
Part of the
Basic Life Sciences
book series (BLSC, volume 49)
Immunoglobulin G (IgG) is a major serum glycoprotein, induced by the presence of foreign proteins. However, in rheumatoid arthritis, it is believed to be chemically altered so that IgG itself is no longer recognised as “self,” and an immune response is generated to this apparently foreign protein.1 This is thought to promote the chronicity of the disease.
KeywordsFluorescent Tryptophan Cysteic Acid Amino Acid Oxidation Tryptophan Metabolite Absorb Amino Acid
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© Plenum Press, New York 1988