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Free Radical Denaturation of Immunoglobulin G is due to Amino Acid Oxidation: Implications for Rheumatoid Arthritis

  • H. R. Griffiths
  • J. Lunec
  • D. R. Blake
  • R. L. Willson
Part of the Basic Life Sciences book series (BLSC, volume 49)

Abstract

Immunoglobulin G (IgG) is a major serum glycoprotein, induced by the presence of foreign proteins. However, in rheumatoid arthritis, it is believed to be chemically altered so that IgG itself is no longer recognised as “self,” and an immune response is generated to this apparently foreign protein.1 This is thought to promote the chronicity of the disease.

Keywords

Fluorescent Tryptophan Cysteic Acid Amino Acid Oxidation Tryptophan Metabolite Absorb Amino Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • H. R. Griffiths
    • 1
  • J. Lunec
    • 1
  • D. R. Blake
    • 1
  • R. L. Willson
    • 2
  1. 1.Departments of Rheumatology and BiochemistrySelly Oak HospitalBirminghamUK
  2. 2.Department of BiochemistryBrunel UniversityLondonUK

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