Effect of Dietary Lipid Peroxides on Lymphoid Tissues
Several studies have been reported of the toxicity and nutritional problems associated with lipid peroxides produced during the autoxidation of oils. Lipid hydroperoxides, the primary oxidation products, and other oxidation products such as ketones, epoxides and aldehydes are thought to be the substances most responsible for the toxicity. (1) However, it has not been shown whether dietary peroxides affect the functions of immunocompetent cells or not. We have reported that methyl U-14C linoleate hydroperoxide and their radioactive secondary oxidation products (carbonyls such as 9-oxo nonanoate and 4-hydroxy nonenal) were absorbed and incorporated into several organs of rats after the oral administration. (2) To appreciate why oxidized oils that occur in foods show lesser nutritional value or toxicity, it seems important to study the effects of dietary peroxides on lymphoid tissues. We studied on the effects on lymphoid tissues of the thymus of mice induced by orally administered methyl linoleate hydroperoxide (MLHPO).
KeywordsLymphoid Tissue Methyl Linoleate Lipid Hydroperoxide Spleen Weight Methyl Linoleate
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- 2.T. Kaneda and T. Miyazawa, Lipid peroxides and nutrition. Wld. Rev. Nutr. Diet. 50:186 (1987).Google Scholar