Lipid Peroxidation and Retinal Phototoxic Degeneration
Phototoxic degeneration of the retina was first described by Noell, Walker, Kang, and Berman in 1966 and these authors also advanced the theory that polyunsaturated fatty acid (PUFA) oxidation was the causal mechanism responsible for photoreceptor cell degeneration.1 Many investigators have contributed to our current understanding of light damage to the retina, and PUFA oxidation continues to be a prominent theory proposed to explain the mechanism of retinal degeneration.2 PUFA oxidation has also been implicated as an important factor in many other degenerative diseases such as cataract and heart disease.3 Until recently, however, conclusive evidence that lipid peroxidation takes place in vivo under any condition has been elusive.
KeywordsOuter Segment Photoreceptor Cell Retinal Degeneration Retinal Tissue Light Damage
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