Prevention by Propionylcarnitine of NADPH and Tert-Butyl Hydroperoxide-Dependent Chemiluminescence in Heart Microsomes

  • M. L. Schinetti
  • D. Rossini
  • A. Bertelli
Part of the Basic Life Sciences book series (BLSC, volume 49)


Carnitine and its esters are essential to the normal functions of various organs playing a central role in fatty acid oxidation. Their acyl buffering action is particularly important in the heart during hypoxic conditions when fatty acids and their metabolites accumulate in the cardiac cell.1,2 Acylcarnitines, such as propionylcarnitine, have been reported to be more effective than carnitine in improving the recovery of cardiac functions after ischemia and the subsequent reperfusion,3 when the sudden restoration of blood flow can lead to free radical generation. Oxygen-derived free radicals can be the initiators of a peroxidative chain, leading to lipid degradation and membrane damage.


Phorbol Myristate Acetate Cumene Hydroperoxide Lipid Degradation Nordihydroguaiaretic Acid Subsequent Reperfusion 
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  1. 1.
    G.J. van der Vusse, and R.S. Reneman, Pharmacological intervention in acute myocardial ischemia and reperfusion, TIPS 6:76 (1985).Google Scholar
  2. 2.
    W.C. Hulsmann, M.L. Dubelaar, and J.M.J. Lamers, Protection by acylcarnitines and phenylmethylsulfonylfluoride of rate heart subjected to ischemia and reperfusion, Biochim. Biophys. Acta 847:62 (1982).CrossRefGoogle Scholar
  3. 3.
    D.J. Paulson, J. Traxler, J. Noonan, and A.L. Shug, Effects of carnitine, acetylcarnitine, proprionylcarnitine, and proprionylcarnitin-taurine amide on the ischemic heart, Fed. Proc. 44:abstract 2058 (1982).Google Scholar
  4. 4.
    J.R. Wright, R.C. Rumbaugh, H.D. Colby, and P.R. Miles, The relationship between chemiluminescence and lipid peroxidation in rate hepatic microsomes, Arch. Biochem. Biophys. 192:344 (1979).PubMedCrossRefGoogle Scholar
  5. 5.
    E. Cadenas and H. Sies, Low level chemiluminescence of liver microsomal fractions initiated by tert-butyl hydroperoxide, Eur. J. Biochem. 124:349 (1982).PubMedCrossRefGoogle Scholar
  6. 6.
    R. Allen, Phagocytic leukocyte oxygenation activities and chemiluminescence: A kinetic approach to analysis, in: “Meth. Enzymol.,” vol. 133, M.A. DeLuca and W.D. McElroy, eds., Academic Press, Inc., Orlando (1986).Google Scholar
  7. 7.
    R. Engler, Granulocytes and oxidative injury in myocardial ischemia and reperfusion, Fed. Proc. 46:2395 (1987).Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • M. L. Schinetti
    • 1
  • D. Rossini
    • 1
  • A. Bertelli
    • 1
  1. 1.Institute of Pharmacology, School of MedicineUniversity of PisaItaly

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