Prevention by Propionylcarnitine of NADPH and Tert-Butyl Hydroperoxide-Dependent Chemiluminescence in Heart Microsomes
Carnitine and its esters are essential to the normal functions of various organs playing a central role in fatty acid oxidation. Their acyl buffering action is particularly important in the heart during hypoxic conditions when fatty acids and their metabolites accumulate in the cardiac cell.1,2 Acylcarnitines, such as propionylcarnitine, have been reported to be more effective than carnitine in improving the recovery of cardiac functions after ischemia and the subsequent reperfusion,3 when the sudden restoration of blood flow can lead to free radical generation. Oxygen-derived free radicals can be the initiators of a peroxidative chain, leading to lipid degradation and membrane damage.
KeywordsPhorbol Myristate Acetate Cumene Hydroperoxide Lipid Degradation Nordihydroguaiaretic Acid Subsequent Reperfusion
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