Advertisement

Platelet Chemiluminiscence Induced by Linoleic and Arachidonic Acids

  • T. Metsä-Ketelä
  • A. Montfoort
  • T. Kunnas
Part of the Basic Life Sciences book series (BLSC, volume 49)

Abstract

Mill et al.1 demonstrated that linoleic acid (18:2N6) and other long-chain fatty acids can induce platelet low-level chemiluminescence. It turned out that only those fatty acids which are susceptible either to enzymatic or autoxidation, e.g., polyunsaturated fatty acids, emit light.

Keywords

Linoleic Acid Arachidonic Acid Human Platelet Fatty Acid Concentration Acid Hydroperoxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    E. L. Mills, J. M. Gerrard, D. Filipovich, J. D. White, and P. G. Qui, The chemiluminescence response of human platelets, J. Clin. Invest., 61:807 (1978).PubMedCrossRefGoogle Scholar
  2. 2.
    P. Wörner, Arachidonic acid-induced chemiluminescence of human platelets: contribution of the prostaglandin and lipoxygenase pathways, Thromb. Haemost., 46:584 (1981).PubMedGoogle Scholar
  3. 3.
    A. Montfoort, C. C. M. Rutten-van Beysterveld, and M. R. Wortelboer, Molecular species of diacylphosphatidylethanolamine in rat and mouse given the same diet, Biochem. Int., 6:569 (1983).PubMedGoogle Scholar
  4. 4.
    J. Verhagen, G. A. Veldink, M. R. Egmond, J. F. G. Vliegenthart, J. Bolding, and J. van der Star, Stedy-state kinetics of the anaerobic reaction of soybean lipoxygenase-1 with linoleic acid and 13-L-hydroperoxylinoleic acid, Biochim. Biophys. Acta, 529:369 (1978).PubMedCrossRefGoogle Scholar
  5. 5.
    E. Seppälä, O. Pora, and T. Metsä-Ketelä, A modified method for extraction and purification of prostaglandin with resin XAD-2, Prostaglandins Leukotrienes Med., 14:235 (1984).CrossRefGoogle Scholar
  6. 6.
    J. B. Smith, and A. L. Willis, Aspirin selectively inhibits prostaglandin production in human platelets, Nature New Biol., 231:235 (1971).PubMedGoogle Scholar
  7. 7.
    D. H. Nugteren, Arachidonate lipoxygenase in blood platelets, Biochim. Biophys. Acta, 380:299 (1975).PubMedCrossRefGoogle Scholar
  8. 8.
    P. Y. K. Wong, P. Westerlund, M. Hamberg, E. Granström, P. H. W. Chao, and Samuelsson, 15-lipoxygenase in human platelets, J. Biol. Chem., 260:9162 (1985).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • T. Metsä-Ketelä
    • 1
  • A. Montfoort
    • 2
  • T. Kunnas
    • 1
  1. 1.Department of Biomedical SciencesUniversity of TampereTampereFinland
  2. 2.Department of Pathology IErasmus UniversityRotterdamThe Netherlands

Personalised recommendations