Electron Spin Resonance of The Semiquinone of The Antitumor Antibiotic Streptonigrin and Its Metal Complexes

  • Helena S. Soedjak
  • Barney L. Bales
  • Joseph Hajdu
Part of the Basic Life Sciences book series (BLSC, volume 49)


Mechanistic elucidation of the redox chemistry of aminoquinone antibiotics exhibiting potent antitumor activity has become one of the most timely problems of cancer chemotherapy today1,2. Specifically, streptronigrin (Figure 1a), is currently regarded as one of the most effective agents for the treatment of a broad spectrum of human cancers3, yet its clinical application is greatly limited due to severe cytotoxicity of the drug. It has been reported that streptonigrin is activated in vivo by one-electron reduction forming the semiquinone4–6 and that the mechanism of antitumor action of streptonigrin depends on participation of metal ions7.


Electron Spin Resonance Electron Spin Resonance Spectrum Cadmium Acetate Potent Antitumor Activity Phenazine Methosulfate 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Helena S. Soedjak
    • 1
  • Barney L. Bales
    • 1
  • Joseph Hajdu
    • 1
  1. 1.Departments of Chemistry and Physics and AstronomyCalifornia State University at NorthridgeNorthridgeUSA

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