Detection of Lipid Peroxidation Products in Lipids and Tissues by Gas Chromatography-Mass Spectrometry
Formation of oxygen radicals and lipid peroxidation have been suggested to play a key role in various types of tissue degeneration and pathology such as heart disease, aging, cancer, and retinal degeneration.1,2 Membrane phospholipids and triglycerides contain the principal deposits of unsaturated fatty acids and are thought to be the primary sites of the lipid peroxidation process. The oxidation of membrane phospholipids has been hypothesized to cause an increase in the permeability of cell membranes and/or to inhibit membrane ion pumps and to lead to cell death. This loss of membrane barrier function is thought to lead to edema, disturbances in electrolyte balance, and elevation of intracellular calcium which contributes to the malfunctioning of cells.
KeywordsLipid Peroxidation Product Electron Capture Detector Cumene Hydroperoxide Linoleate Hydroperoxide Lipid Peroxidation Process
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