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Fenton Reactions in Lipid Phases: Iron Solubility, Oh Production, and Initiation of Lipid Oxidation

  • K. M. Schaich
  • D. C. Borg
Part of the Basic Life Sciences book series (BLSC, volume 49)

Abstract

There has been much discussion in this meeting regarding the involvement of hydroxyl radicals (OH), oxidizing lipids, and metal ions in oxidative damage in living tissue and in food systems. However, the causal relationships linking these three species to each other and to specific damage in cells have not yet been clarified. Indeed, the literature is replete with contradictory claims regarding their activity and effects.

Keywords

Oleic Acid Electron Paramagnetic Resonance Electron Paramagnetic Resonance Spectrum Lipid Oxidation Methyl Linoleate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    D. С. Borg and K. M. Schaich, Cytotoxicity from coupled redox cycling of autoxidizing xenobiotics and metals, Isr. J. Chem. 24:38 (1984).Google Scholar
  2. 2.
    S. Goldstein and G. Czapski, The role and mechanism of metal ions and their complexes in enhancing damage in biological systems or in protecting these systems from the toxicity of O2, J. Free Rad. Biol. Med. 2:3 (1986).CrossRefGoogle Scholar
  3. 3.
    K. M. Schaich and D. C. Borg, Fenton reactions in lipid phases, Lipids 23:in press (1988).Google Scholar
  4. 4.
    D. С Borg, K. M. Schaich, and A. Forman, Autoxidative cytotoxicity: Is there metal-independent formation of hydroxyl radicals? Are there “crypto-hydroxyl” radicals?, in: “Oxygen Radicals in Chemistry and Biology,” W. Bors, M. Saran, and D. Tait, eds., Walter de Gruyter, Berlin (1984).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • K. M. Schaich
    • 1
  • D. C. Borg
    • 1
  1. 1.Medical DepartmentBrookhaven National LaboratoryUptonUSA

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