Anterior Chamber Hydrogen Peroxide: Effects of 3-Aminotriazole on Peroxide Kinetics and on the Status of Glutathione
Previous studies using in vitro methods have shown that the anterior segment tissues, particularly the corneal endothelium, have the capacity to handle excess superoxide anion, but the capability to detoxify hydrogen peroxide can be exceeded. The data indicated that, of all the phototoxic by-products, hydrogen peroxide was the compound capable of inducing the most damage in the anterior segment of the eye.1–3
KeywordsCatalase Activity Anterior Chamber Aqueous Humor Anterior Segment Ocular Tissue
Unable to display preview. Download preview PDF.
- 1.D.S. Hull, S. Csukas, K. Green, and V. Livingston. Hydrogen peroxide and corneal endothelium. Acta Ophthalmol. 59:409 (1981).Google Scholar
- 3.D.S. Hull, K. Green, and R.D. Elijah. Effect of oxygen free radical products on iris vascular permeability. Acta Ophthalmol. 63:513 (1985).Google Scholar
- 8.A. Costarides, D. Birnbaum, S. Csukas, E. Forbes, and K. Green. Morphological sequelae of anterior segment hydrogen peroxide in young and adult rabbits with or without 3-aminotriazole treatment, in: “Oxygen Radicals in Biology and Medicine,” M. Simic, J. Ward and K. Taylor, eds., Plenum Press, New York (1988).Google Scholar