Oxygen-Induced Retinopathy in the Rat

  • John S. Penn
  • Lisa A. Thum
Part of the Basic Life Sciences book series (BLSC, volume 49)


Through a decade of research, peroxidation has been implicated in human retinal degenerations. Ocular siderosis, or iron in the eye, has long been known to result in retinal degeneration. Certain retinotoxic drugs, such as adriamycin, are believed to act by peroxidative mechanisms. The retina can also be damaged by excess light, presumably through photo-oxidative processes. Senile macular degeneration is yet another candidate for peroxidation-induced degeneration. Finally, retinopathy of prematurity occurs only in premature infants housed in elevated levels of atmospheric oxygen. Although the agent in each of these insults may be different, cell destruction and death apparently proceed through pathways common to lipid or protein oxidation.


Premature Infant Retinal Degeneration Retinal Vasculature Retinal Degenerative Disease Retrolental Fibroplasia 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • John S. Penn
    • 1
  • Lisa A. Thum
    • 1
  1. 1.Cullen Eye InstituteBaylor College of MedicineHoustonUSA

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