Hydrogen Peroxide Production in Dopamine Neurons

  • Mary Beth Spina
  • Gerald Cohen
Part of the Basic Life Sciences book series (BLSC, volume 49)


Hydrogen peroxide (H2O2) is an oxidant that is hazardous to neurons. A major cellular mechanism for the detoxification of hydrogen peroxide is through the glutathione peroxidase/glutathione reductase pathway. The oxidation of reduced glutathione (GSH) by glutathione peroxidase results in the formation of oxidized glutathione (GSSG). Increased steady-state levels of GSSG can provide an index of oxidative stress.


Nerve Terminal Monoamine Oxidase Dopamine Neuron Oxidize Glutathione GSSG Level 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Mary Beth Spina
    • 1
  • Gerald Cohen
    • 1
  1. 1.Biomedical Sciences Doctoral Program (Neurobiology), Department of Neurology, and Neurobiology Center, Mount Sinai School of MedicineCity University of New YorkNew YorkUSA

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