Hydrogen Peroxide Production in Dopamine Neurons

  • Mary Beth Spina
  • Gerald Cohen
Part of the Basic Life Sciences book series (BLSC, volume 49)


Hydrogen peroxide (H2O2) is an oxidant that is hazardous to neurons. A major cellular mechanism for the detoxification of hydrogen peroxide is through the glutathione peroxidase/glutathione reductase pathway. The oxidation of reduced glutathione (GSH) by glutathione peroxidase results in the formation of oxidized glutathione (GSSG). Increased steady-state levels of GSSG can provide an index of oxidative stress.


Nerve Terminal Monoamine Oxidase Dopamine Neuron Oxidize Glutathione GSSG Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    G. Cohen, The pathobiology of Parkinson’s disease: Biochemical aspects of dopamine neuron senescence, J. Neural Trans. Suppl. 19:89 (1983).Google Scholar
  2. 2.
    F. Tietze, Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Application to mammalian blood and other tissues, Anal. Biochem. 27:502 (1969).PubMedCrossRefGoogle Scholar
  3. 3.
    H. Sies, Hydroperoxides and thiol oxidants in the study of oxidative stress in intact cells and organs, in: “Oxidative Stress,” H. Sies, ed., Academic Press Inc., London, (1983).Google Scholar
  4. 4.
    N. Oshino and B. Chance, Properties of glutathione release observed during the reduction of organic hydroperoxide, demethylation of aminopyrine and oxidation of some substances in perfused rat liver, and their implications for the physiological function of catalase, Biochem. J. 162:509 (1977).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Mary Beth Spina
    • 1
  • Gerald Cohen
    • 1
  1. 1.Biomedical Sciences Doctoral Program (Neurobiology), Department of Neurology, and Neurobiology Center, Mount Sinai School of MedicineCity University of New YorkNew YorkUSA

Personalised recommendations