Hydrogen Peroxide Production in Dopamine Neurons
Hydrogen peroxide (H2O2) is an oxidant that is hazardous to neurons. A major cellular mechanism for the detoxification of hydrogen peroxide is through the glutathione peroxidase/glutathione reductase pathway. The oxidation of reduced glutathione (GSH) by glutathione peroxidase results in the formation of oxidized glutathione (GSSG). Increased steady-state levels of GSSG can provide an index of oxidative stress.
KeywordsNerve Terminal Monoamine Oxidase Dopamine Neuron Oxidize Glutathione GSSG Level
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