Inhibition by Prostacyclin Analogs of ·O2- Production in Human Polymorphonuclear Leukocytes

  • H. J. Stahlberg
  • G. Loschen
  • L. Flohé
Part of the Basic Life Sciences book series (BLSC, volume 49)


While the interactions of prostacyclin with platelets have been intensively studied during the last decade1,2 only very few and sometimes contradictory data point to an interaction of prostacyclin with stimulated leukocytes. The following events, which are inducible in polymorphonuclear leukocytes (PMNL) during inflammatory reactions, were reported to be inhibited by prostacyclin and PGE1: leukotaxis,3 degranulation of lytic enzymes,4 adherence to endothelial cells,5 oxygen radical formation.6 An elevation of cAMP in stimulated leukocytes by prostacyclin has also been described.7


Radical Formation Polymorphonuclear Leukocyte Human Polymorphonuclear Leukocyte cAMP Elevation Colloidal Silica Particle 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • H. J. Stahlberg
    • 1
  • G. Loschen
    • 1
  • L. Flohé
    • 1
  1. 1.Center of ResearchGrünenthal GmbHAachenFederal Republic of Germany

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