Prostaglandins and Leukotrienes in Pulmonary O2 Toxicity
O2 radicals can initiate peroxidation of cellular membranes, resulting in the release of hydrolytic enzymes, decreased membrane fluidity, and compromised membrane integrity. Free radicals also may cause the release of vasoactive substances, including prostaglandins (PG) and leukotrienes (LT). These products of the arachidonic acid cascade have been shown to produce vasoconstriction, vasodilation, platelet aggregation, increased capillary permeability, plasma extravasation, and edema formation. Of interest is that a similar pathophysiology is seen after O2 exposure. Employing the isolated perfused lung (IPL) prepared from lungs of rats exposed to 100% O2, the role of PG and LT in O2-induced lung damage was studied.
KeywordsCapillary Permeability Plasma Extravasation Arachidonic Acid Cascade Hyperoxic Exposure Lung Damage
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