Alterations in Cultured Rat Pulmonary Artery Endothelial Cells with Hyperoxia; Effect of Age
The integrity of the vascular endothelial cell layer is vital in separating the intravascular system from the parenchyma and thus in preserving whole-organ structure and function. As endothelial cells interface directly with the blood, they are exposed to relatively high concentrations of oxygen and its associated toxic metabolites. In order to adapt to this hyperoxic stress, the endothelial cells have evolved various antioxidant defense systems, including the enzymes superoxide dismutase (SOD) and catalase (CAT).1
KeywordsMature Cell Senescent Cell Enzyme Superoxide Dismutase Johns Hopkins Medical Institution High Oxygen Level
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