Alterations in Cultured Rat Pulmonary Artery Endothelial Cells with Hyperoxia; Effect of Age

  • R. S. Chuknyiska
  • R. E. Ratych
Part of the Basic Life Sciences book series (BLSC, volume 49)


The integrity of the vascular endothelial cell layer is vital in separating the intravascular system from the parenchyma and thus in preserving whole-organ structure and function. As endothelial cells interface directly with the blood, they are exposed to relatively high concentrations of oxygen and its associated toxic metabolites. In order to adapt to this hyperoxic stress, the endothelial cells have evolved various antioxidant defense systems, including the enzymes superoxide dismutase (SOD) and catalase (CAT).1


Mature Cell Senescent Cell Enzyme Superoxide Dismutase Johns Hopkins Medical Institution High Oxygen Level 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • R. S. Chuknyiska
    • 1
  • R. E. Ratych
    • 1
  1. 1.Department of Surgery, Francis Scott Key Medical CenterThe Johns Hopkins Medical InstitutionsBaltimoreUSA

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