The Role of Iron in Injury of Endothelial Cells in Vitro and in Vivo
Injury of cells and organs resulting from the generation of oxygen-derived free radicals is now a well-accepted observation (reviewed 1). Both the in vitro as well as the in vivo generation of oxygen radicals from activated phagocytic cells (neutrophils, eosinophils, monocytes and macrophages) via activation of NADPH oxidase results in injury of eukaryotic and prokaryotic cells (reviewed 1). All our studies have focused on acute injury of the rat lung and in vitro destruction of endothelial cells in an attempt to define the mechanisms of cell injury. What will be reviewed in this communication is the evidence for the critical role of iron in oxygen-radical-mediated cell injury and a linkage between these reactions and the appearance of products of lipid peroxidation.
KeywordsLung Injury Acute Lung Injury Human Neutrophil Phorbol Ester Iron Chelator
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- 1.J.C. Fantone and P.A. Ward, Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions. Amer. J. Pathol. 107:395 (1982).Google Scholar