Oxygen Radical Scavengers and Myocardial Preservation during Transplantation: Role of Xanthine Oxidase

  • James R. Stewart
  • Walter H. Merrill
  • William H. Frist
Part of the Basic Life Sciences book series (BLSC, volume 49)


Cardiac transplantation has emerged as an important therapeutic option in the treatment of end-stage heart disease. Advances in surgical techniques in the ′50s and ′60s and myocardial preservation and immunosuppressive therapy in the ′70s have been responsible for the current success of cardiac transplantation in the ′80s. Advances in myocardial preservation used in non-transplant heart surgery have been applied to the preservation of the donor heart during its procurement, transport, and implantation. In optimal situations the generally accepted limit of hypothermic preservation of the human heart for transplantation is approximately four hours.


Infarct Size Left Anterior Descend Xanthine Oxidase Cardioplegic Solution Xanthine Oxidase Activity 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • James R. Stewart
    • 1
  • Walter H. Merrill
    • 1
  • William H. Frist
    • 1
  1. 1.Department of Cardiac and Thoracic SurgeryVanderbilt UniversityNashvilleUSA

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