Plasma Lipid Peroxidation and Atherosclerosis in Restricted Ovulator Chickens
Restricted ovulator (RO, also called non-layer or NL) chickens carry a genetic mutation which results in the cessation of egg laying’ when under a prolonged photoperiod. As a consequence these chickens develop an extreme hyperlipidemia with blood lipid levels over 3,000 mg/triglyceride dl and 700 mg/dl cholesterol. Within 12 months these chickens develop atherosclerotic lesions in both the coronary artery1 and aorta2. It was originally assumed the hyperlipidemia was responsible for the higher rate of atherosclerosis in these chickens. However, we also found a significant increase in plasma lipid peroxidation in R0 chickens. This increase in peroxidation correlates closely with the triglyceride levels.
KeywordsIntimal Thickening Blood Lipid Level Plasma Lipid Peroxidation Serum Lipid Peroxidation Chronic Cigarette Smoker
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- 6.R. G. D. Steel and J. H. Torrie, Principles and Procedures of Statistics, McGraw-Hill Book Co., Inc., New York (1960).Google Scholar
- 8.S. Moncada, R.J. Gryglewski, S. Bunting and J.R. Vance, A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxide the substance which prevents platelet aggregation. Prostaglandin 12:715 (1960).Google Scholar
- 10.Y. Goto, Lipid peroxides as a cause of vascular diseases. In: “Lipid Peroxides in Biology and Medicine,” K. Yagi, ed. Academic Press, City, (1982).Google Scholar
- 13.K. Yagi, H. Ohkawa, N. Ohisi, M. Yamashita, and T. Nakashima. Lesion of aortic intima caused by intravenous administration of linoleic and hydroperoxide. J. Appl. Biochem. 3:58 (1981).Google Scholar