Plasma Lipid Peroxidation and Atherosclerosis in Restricted Ovulator Chickens

  • Terrance L. Smith
  • Fred A. Kummerow
Part of the Basic Life Sciences book series (BLSC, volume 49)


Restricted ovulator (RO, also called non-layer or NL) chickens carry a genetic mutation which results in the cessation of egg laying’ when under a prolonged photoperiod. As a consequence these chickens develop an extreme hyperlipidemia with blood lipid levels over 3,000 mg/triglyceride dl and 700 mg/dl cholesterol. Within 12 months these chickens develop atherosclerotic lesions in both the coronary artery1 and aorta2. It was originally assumed the hyperlipidemia was responsible for the higher rate of atherosclerosis in these chickens. However, we also found a significant increase in plasma lipid peroxidation in R0 chickens. This increase in peroxidation correlates closely with the triglyceride levels.


Intimal Thickening Blood Lipid Level Plasma Lipid Peroxidation Serum Lipid Peroxidation Chronic Cigarette Smoker 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Terrance L. Smith
    • 1
  • Fred A. Kummerow
    • 1
  1. 1.Burnsides Research LaboratoryUrbanaUSA

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