Potential of Methylene Blue to Block Oxygen Radical Generation in Reperfusion Injury
Superoxide and hydroxyl radical generation have been implicated in a variety of pathological conditions, including ischemic injury in myocardial, renal, and skin-flap tissue, as reperfusion of the ischemic tissue presumably leads to a burst of free radical generation 1–4,14. Tissue hypoxia during ischemia results in the conversion of xanthine dehydrogenase to xanthine oxidase and concomitant breakdown of ATP to hypoxanthine 14. Upon reperfusion the xanthine oxidase oxidizes the hypoxanthine, and large quantities of superoxide, hydrogen peroxide, and possibly hydroxyl radicals are produced. Previous attempts to inhibit oxygen radical toxicity have focused on removing the superoxide or hydroxyl radicals after their production.
KeywordsUric Acid Methylene Blue Xanthine Oxidase Molybdenum Disulfide Flavin Adenine Dinucleotide
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