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Equieffective Protection by Human and Bovine SOD Against Renal Reperfusion Damage in Rats

  • Johannes Schneider
  • Elmar Friderichs
  • Hubert Giertz
Part of the Basic Life Sciences book series (BLSC, volume 49)

Abstract

Oxygen-derived free radicals are considered to cause postischemic tissue injury in many tissues.1,2 in ischemic and reoxygenated kidneys of different animal species comparable protective effects have been obtained by allopurinol pretreatment or superoxide dismutase infused concomitantly with reoxygenation.3,4 These observations indicate that the free radical damage is initiated by superoxide ions possibly generated by xanthine oxidase,1 although the precise mechanism of superoxide formation and the cascade of pathogenic events resulting therefrom is still debated.

Keywords

Xanthine Oxidase Renal Ischemia Inulin Clearance Ischemic Acute Renal Failure Human Superoxide Dismutase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    J. M. McCord, Oxygen-derived free radicals in postischemic tissue injury, N. Engl, J. Med. 312: 159 (1985).CrossRefGoogle Scholar
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    R. A. Weisiger, Oxygen radicals and ischemic tissue injury, Gastroenterology 90: 494 (1986)PubMedGoogle Scholar
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    M. S. Palier, J. R. Hoidal, and Th. F. Ferris, Oxygen free radicals in ischemic acute renal failure in the rat, J. Clin. Invest. 74: 1156 (1984).CrossRefGoogle Scholar
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    K. Ouriel, N.G. Smedira, and J. J. Ricotta, Protection of the kidney after temporary ischemia: Free radical scavengers, J. Vase. Surg. 2: 49 (1985).Google Scholar
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    R. A. Hallewell, F. R. Masiarz, R. C. Najarian, J. P. Puma, M. R. Quiroga, A. Randolph, R. Sanchez-Pescador, C. J. Scandella, B. Smith, K. S. Steimer, and G. T. Müllenbach, Human Cu/Zn superoxide dismutase CDNA: Isolation of clones synthetizing high levels of active or inactive enzyme from an expression library, Nucleic Acids Res. 13: 2017 (1985).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Johannes Schneider
    • 1
  • Elmar Friderichs
    • 1
  • Hubert Giertz
    • 1
  1. 1.Center of ResearchGrünenthal GmbHAachenGermany

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