Equieffective Protection by Human and Bovine SOD Against Renal Reperfusion Damage in Rats
Oxygen-derived free radicals are considered to cause postischemic tissue injury in many tissues.1,2 in ischemic and reoxygenated kidneys of different animal species comparable protective effects have been obtained by allopurinol pretreatment or superoxide dismutase infused concomitantly with reoxygenation.3,4 These observations indicate that the free radical damage is initiated by superoxide ions possibly generated by xanthine oxidase,1 although the precise mechanism of superoxide formation and the cascade of pathogenic events resulting therefrom is still debated.
KeywordsXanthine Oxidase Renal Ischemia Inulin Clearance Ischemic Acute Renal Failure Human Superoxide Dismutase
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- 4.K. Ouriel, N.G. Smedira, and J. J. Ricotta, Protection of the kidney after temporary ischemia: Free radical scavengers, J. Vase. Surg. 2: 49 (1985).Google Scholar
- 5.R. A. Hallewell, F. R. Masiarz, R. C. Najarian, J. P. Puma, M. R. Quiroga, A. Randolph, R. Sanchez-Pescador, C. J. Scandella, B. Smith, K. S. Steimer, and G. T. Müllenbach, Human Cu/Zn superoxide dismutase CDNA: Isolation of clones synthetizing high levels of active or inactive enzyme from an expression library, Nucleic Acids Res. 13: 2017 (1985).PubMedCrossRefGoogle Scholar