The Amplificative Role of PAF-Acether in the Oxidative Stress Following Reperfusion of Ischemic Stomach

  • Marie-Therese Droy-Lefaix
  • Yvette Drouet
  • Gerard Geraud
  • Pierre Braquet
Part of the Basic Life Sciences book series (BLSC, volume 49)


It is now well demonstrated that neutrophil infiltration during ischemia-reperfusion may be responsible for tissue injury.1 In conjunction with an oxidative burst, neutrophils can generate oxygen free radicals such as superoxide anion or hydrogen peroxide. These oxygen metabolites can produce the hydroxyl radical which is particularly toxic to cells.2,3


Gastric Mucosa Xanthine Oxidase Neutrophil Infiltration Arterial Occlusion Protected Gastric Mucosa 
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  1. 1.
    M. C. Grisham, L. A. Hernandez, and D. N. Granger, Xanthine oxidase and neutrophil infiltration in intestinal ischemia, Am. J. Physiol. 251:G567 (1986).PubMedGoogle Scholar
  2. 2.
    J. C. Fantone and P. A. Ward, Role of oxygen-derived free radicals and metabolites in leukocyte — dependent inflammatory reactions, Am. J. Pathol. 107:397 (1982).Google Scholar
  3. 3.
    R. T. Briggs, J. M. Robinson, M. L. Karnovsky, and M. J. Karnovsky, Superoxide production by polymorphonuclear leukocytes, Histochemistry 84:371 (1986).PubMedCrossRefGoogle Scholar
  4. 4.
    M. Sanchez-Crespo, F. Alonso, G. M. Garcia, J. Gomez-Cambronero, and M.L. Nieto, Synthesis of plateletactivating factor from human polymorphonuclear leukocytes:Regulation and pharmacological approaches, Int. J. Tiss. Reac. VII:345 (1985).Google Scholar
  5. 5.
    P. Braquet, A. Etienne, J. M. Mencia-Huerta, and F. Clostre, Possible role of Platelet-activating factor in gastrointestinal ulcerations as evidenced by the use of the specific antagonists, BN 52021 and BN 52063, Pharmacol. Research Commun, in press.Google Scholar
  6. 6.
    J. L. Wallace and B. J. R. Whittle, Inhibition of endotoxin-induced gastrointestinal plasma leakage by PGE2 and a PAF-antagonist, Gastroenterology 92:1685 (1987).Google Scholar
  7. 7.
    J. C. Gay, J. K. Beckman, K. A. Zaboy, and J. N. Lukens, Modulation of neutrophil oxidative responses of soluble stimuli by platelet-activating factor, Blood 67:931 (1986).PubMedGoogle Scholar
  8. 8.
    P. Braquet, B. Spinnewyn, M. Braquet, R. H. Bourgain, J. F. Taylor, A. Etienne, and K. Drieu, BN 52021 and related compounds:A new series of hightly specific PAF-acether receptor antagonists isolated from Ginkgo biloba, Blood Vessels 6:559 (1985).Google Scholar
  9. 9.
    J. P. Arnould, J. M. Zahm, G. Pottier, C. Duvivier, and E. Puchelle, A new apparatus for measuring the thread-forming property (spinabi-lity) of biological fluids, Biorheology 1:123 (1984).Google Scholar
  10. 10.
    J. M. McCord and R. S. Roy, The pathophysiology of superoxide:Roles in inflammation and ischemia, Can. J. Physiol. 60:1346 (1982).CrossRefGoogle Scholar
  11. 11.
    D. N. Granger, G. Rutili, and J. M. McCord, Superoxide radicals in feline intestinal ischemia, Gastroenterology 81:22 (1981).PubMedGoogle Scholar
  12. 12.
    D. A. Parks, A. K. Shah, and D. N. Granger, Oxygen radicals:Effects on intestinal vascular permeability, Am. J. Physiol. 247:G167 (1984).PubMedGoogle Scholar
  13. 13.
    M. Itoh and P. H. Guth, Role of oxygen-derived free radicals in hemorrhagic shock induced gastric lesions in the rat, Gastroenterology 88:1162 (1985).PubMedGoogle Scholar
  14. 14.
    D. N. Granger, M. E. Hollwarth, and D. A. Parks, Ischemia-reperfusion injury.Role of oxygen-derived free radicals, Acta Physiol. Scand. 548:47 (1986).Google Scholar
  15. 15.
    A. Rosam, J. L. Wallace, and B. J. R. Whittle, Potent ulcerogenic actions of platelet-activating factor on the stomach. Nature 319:54 (1986).PubMedCrossRefGoogle Scholar
  16. 16.
    N. W. R. Wickham, G. M. Vercelotti, H. Q. Yin, С F. Moldow, and H. S. Jacob, Neutrophils are printed to release toxic oxidants by contact with thrombinstimulated endothelium:Role of endothelial cell generated platelet activating factor, Fed. Proc, in press.Google Scholar
  17. 17.
    B. Spinnewyn, N. Blavet, F. Clostre, N. Bazan, and P. Braquet, Involvement of platelet-activating factor (PAF) in cerebral post-ischemic phase in mongolian gerbils, Prostaglandins, in press.Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Marie-Therese Droy-Lefaix
    • 1
  • Yvette Drouet
    • 1
  • Gerard Geraud
    • 1
  • Pierre Braquet
    • 1
  1. 1.Institut Henri BeaufourLe Plessis RobinsonFrance

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