Mechanisms of Oxidant-Mediated Microvascular Injury Following Reperfusion of the Ischemic Intestine

  • Barbara J. Zimmerman
  • Matthew B. Grisham
  • D. Neil Granger
Part of the Basic Life Sciences book series (BLSC, volume 49)


It is now well recognized that ischemia/reperfusion-induced tissue injury is a major factor in the pathogenesis of certain life threatening diseases such as stroke and coronary artery disease. Studies indicate that this injury occurs at the time of reperfusion rather than during the period of ischemia. There is now a large body of experimental data which suggests that oxy radicals mediate the microvascular and parenchymal cell damage observed during reperfusion of ischemic tissues. Reactive oxygen metabolites have been implicated in ischemia/reperfusion injury in the small intestine, heart, liver, pancreas, and brain.


Xanthine Oxidase Neutrophil Infiltration Reactive Oxygen Metabolite Xanthine Dehydrogenase Microvascular Injury 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Barbara J. Zimmerman
    • 1
  • Matthew B. Grisham
    • 1
  • D. Neil Granger
    • 1
  1. 1.Department of Physiology and BiophysicsLouisiana State University Medical CenterShreveportUSA

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