Clastogenic Factor in Ischemia-Reperfusion Injury: Protective Effect of Allopurinol

  • Ingrid Emerit
  • Jean-Noel Fabiani
Part of the Basic Life Sciences book series (BLSC, volume 49)


Many studies have established a major role for toxic metabolites of oxygen as mediators of tissue injury following ischemia-reperfusion in a wide variety of species and organs.1–3 The source of the oxygen free radicals is still the subject of debate. Tissue damage may be due in part to direct radical attack, in part to longer-lived secondary compounds derived from lipid peroxidation of membranes.


Xanthine Oxidase Coronary Sinus Chromosome Damage Myocardial Reperfusion Injury Aberration Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    J.M. McCord, Oxygen-derived free radicals in post-ischemic tissue injury, New Eng. J. Med. 312:159 (1985).CrossRefPubMedGoogle Scholar
  2. 2.
    D.A. Peterson, R.W. Asinger, K.J. Elsperger, D.C. Homans and J.W. Eaton, Reactive oxygen species may cause myocardial reperfusion injury, Biochem. Biophys. Res. Comm. 127:87 (1985).CrossRefPubMedGoogle Scholar
  3. 3.
    D.N. Granger, M.E. Hollwarth and D.A. Parks, Ischemia-reperfusion injury: role of oxygen-derived free radicals, Acta Physiol. Scand. 548:47 (1986).Google Scholar
  4. 4.
    I. Emerit, Chromosome breakage factors: origins and possible significance, Progr. Mutat. Res. 4:61 (1982).Google Scholar
  5. 5.
    I. Emerit, Properties and action mechanism of clastogenic factors, in: “Lyxmphokines,” Edgar Pick, ed., Academic Press, (1983).Google Scholar
  6. 6.
    I. Emerit and P. Cerutti, Tumor promoter phorbol-myristate-acetate induces a clastogenic factor in human lymphocytes, Proc. Natl. Acad. Sci. USA 79:7509 (1982).CrossRefPubMedGoogle Scholar
  7. 7.
    I. Emerit, S.H. Khan and P. Cerutti, Treatment of lymphocyte cultures with a hypoxanthine-xanthine oxidase system induces the formation of transferable clastogenic material, J. Free Radicals Bio. Med. 1:51 (1985).CrossRefGoogle Scholar
  8. 8.
    R. Jolly, W.J. Kane, M.B. Bailie, G.D. Abrams and B.R. Lucchesi, Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase, Circ. Res. 54:277 (1984).CrossRefPubMedGoogle Scholar
  9. 9.
    D.E. Chambers, D.A. Parks, G. Patterson, S. Yoshida, K. Burton, L.F. Parmley, J.M. McCord and J. M. Downey, Role of oxygen derived radicals in myocardial ischemia, Fed. Proc. 47:1093 (1983).Google Scholar
  10. 10.
    J.N. Fabiani, J. Relland and A. Carpentier, Myocardial protection via the coronary sinus in cardiac surgery: comparative evaluation of two techniques, in: “The Coronary Sinus,” W. Mohl, ed., Steinkopff Verlag Darmstadt (1984).Google Scholar
  11. 11.
    D.V. Godin and S. Bhimji, Effects of allopurinol on myocardial ischemic injury induced by coronary artery ligation and reperfusion, Biochem. Pharmacol. 36:2101 (1987).CrossRefPubMedGoogle Scholar
  12. 12.
    J.L. Zweier, J.T. Flaherty and M.L. Weisfeldt, Direct measurement of free radical generation following reperfusion of ischemic myocardium. Proc. Natl. Acad. Sci. USA 84:1404 (1987).CrossRefPubMedGoogle Scholar
  13. 13.
    A.D. Romaschin, G.J. Wilson and D.A.G. Mickle, Hydroxy-conjugated dienes, products of free radical attack on polyunsaturated phospholipids in reversibly and irreversibly ischemic myocardium, Symposium on “Free Radicals in Biology and Medicine: Ischemia/Reperfusion Injury.” Point Clear, Alabama, March 17–19 (1986).Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Ingrid Emerit
    • 1
  • Jean-Noel Fabiani
    • 2
  1. 1.Laboratoire de Genetique, Institute Biochemical des CorderliersCNRS-Universite Paris VIParisFrance
  2. 2.Clinique de Chirurgie CardiovasculaireHopital BroussaisParisFrance

Personalised recommendations