Clastogenic Factor in Ischemia-Reperfusion Injury: Protective Effect of Allopurinol
Many studies have established a major role for toxic metabolites of oxygen as mediators of tissue injury following ischemia-reperfusion in a wide variety of species and organs.1–3 The source of the oxygen free radicals is still the subject of debate. Tissue damage may be due in part to direct radical attack, in part to longer-lived secondary compounds derived from lipid peroxidation of membranes.
KeywordsXanthine Oxidase Coronary Sinus Chromosome Damage Myocardial Reperfusion Injury Aberration Rate
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