Superoxide Generation of Phagocytizing Polymorphonuclear Leukocytes from Patients with Chronic Renal Failure
Patients with chronic renal failure (CRF) are susceptible to microorganisms and often suffer from severe infection. Whether this is caused in part by decreased generation of active oxygen by polymorphonuclear leukocytes (PMN) is unclear. Active oxygen generation by PMN in CRF has been reported to be augumented (NBT reduction assay),1 normal (NBT reduction assay, cytochrome C reduction assay),2,3 decreased (luminol-dependent chemiluminescence).3
KeywordsUric Acid Chronic Renal Failure Xanthine Oxidase Polymorphonuclear Leukocyte Active Oxygen Species
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