Oxidative Inactivation of Neutrophil Granule Proteinases: Implications for Neutrophil-Mediated Proteolysis

  • Margret C. M. Vissers
  • Christine C. Winterbourn
Part of the Basic Life Sciences book series (BLSC, volume 49)


Oxidants released by stimulated neutrophils are likely contributors to tissue damage at sites of inflammation. One way they could act would be to modify structural components of the tissue to enhance their susceptibility to proteolytic digestion. In that neutrophils concurrently release oxidants and granule proteinases, this would be a mechanism where the two could act synergistically.


Glomerular Basement Membrane Chronic Granulomatous Disease Collagen Degradation Oxidative Inactivation Neutrophil Granule 


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  1. 1.
    M.C.M. Vissers and C.C. Winterbourn, The effect of oxidants on neutrophil-mediated degradation of glomerular basement membrane collagen. Biochim. Biophys. Acta, 889:277 (1986).PubMedCrossRefGoogle Scholar
  2. 2.
    A.A. Voetman, R.S. Weening, M.N. Hamers, L.J. Meerhof, A.A.M. Bot and D. Roos, Phagocytosing human neutrophils inactivate their own granular enzymes. J. Clin. Invest., 67:1541 (1981).PubMedCrossRefGoogle Scholar
  3. 3.
    R.A. Clark and N. Borregaard, Neutrophils autoinactivate secretory products by myeloperoxidase-catalysed oxidation. Blood, 65:375 (1985).PubMedGoogle Scholar
  4. 4.
    M.C.M. Vissers and C.C. Winterbourn, Myeloperoxidase-dependent oxidative inactivation of neutrophil neutral proteinases and microbicidal enzymes. Biochem. J., 245:277 (1987).PubMedGoogle Scholar
  5. 5.
    S.J. Weiss, G. Peppin, X. Ortiz, C. Ragsdale and S.T. Test, Oxidative autoactivation of latent collagenase by human neutrophils. Science, 227:747 (1985).PubMedCrossRefGoogle Scholar
  6. 6.
    G.J. Peppin and S.J. Vfeiss, Activation of the endogenous metalloproteinase, gelatinase, by triggered human neutrophils. Proc. Natl. Acad. Sci. U.S.A., 83:4322 (1986).PubMedCrossRefGoogle Scholar
  7. 7.
    M.C.M. Vissers and C.C. Winterbourn, Activation of human neutrophil gelatinase by endogenous serine proteinases. Biochem. J. 249:327 (1988).PubMedGoogle Scholar
  8. 8.
    M.C.M. Vissers, C.C. Winterbourn and J.S. Hunt, Degradation of glomerular basement membrane by human neutrophils in vitro. Biochim. Biophys. Acta, 804:154 (1984).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Margret C. M. Vissers
    • 1
  • Christine C. Winterbourn
    • 1
  1. 1.Pathology DepartmentChristchurch School of MedicineChristchurchNew Zealand

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