Oxidative Inactivation of Neutrophil Granule Proteinases: Implications for Neutrophil-Mediated Proteolysis
Oxidants released by stimulated neutrophils are likely contributors to tissue damage at sites of inflammation. One way they could act would be to modify structural components of the tissue to enhance their susceptibility to proteolytic digestion. In that neutrophils concurrently release oxidants and granule proteinases, this would be a mechanism where the two could act synergistically.
KeywordsGlomerular Basement Membrane Chronic Granulomatous Disease Collagen Degradation Oxidative Inactivation Neutrophil Granule
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