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Reactions of Myeloperoxidase with Superoxide and Hydrogen Peroxide: Signficance for its Function in the Neutrophil

  • Christine C. Winterbourn
  • Anthony J. Kettle
Part of the Basic Life Sciences book series (BLSC, volume 49)

Abstract

Myeloperoxidase (MPO) in its purified form acts as a conventional peroxidase and, in addition, catalyses the reaction It has a pH optimum of 5–6, but shows some activity at neutral pH. HOCl and the MPO-H2O2-Cl- system are very reactive with most biological molecules, and both are potently microbicidal. Thus the MPO system seems the ideal candidate to provide the neutrophil with antimicrobial activity.

Keywords

Superoxide Dismutase Xanthine Oxidase Superoxide Dismutase Activity Hypochlorous Acid Hydroxyl Radical Production 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Christine C. Winterbourn
    • 1
  • Anthony J. Kettle
    • 1
  1. 1.Pathology DepartmentChristchurch School of MedicineChristchurchNew Zealand

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