Advertisement

Lipid Peroxidation and Haloalkylation in CCl4-Induced Liver Fatty Degeneration and Necrosis

  • Giuseppe Poli
  • Elena Chiarpotto
  • Fiorella Biasi
  • Emanuele Albano
  • Rita Carini
  • Umberto M. Marinari
  • Mario U. Dianzani
Part of the Basic Life Sciences book series (BLSC, volume 49)

Abstract

Liver fatty accumulation following acute CCl4 poisoning is triggered by a block of lipoprotein secretion which occurs very soon after treatment.1,2 Various steps of the secretory pathway are probably involved in the expression of such damage. Recent studies with isolated rat hepatocytes have shown a marked impairment of the maturation and transport of lipoprotein micelles at the level of the Golgi apparatus soon after poisoning with CCl4.3. In the present paper the demonstration of early disturbances of liver Golgi function occurring in the whole animal dosed with CCl4 is reported, together with studies on the pathogenesis of this cellular perturbation. In addition, the relative role played by CCl4-dependent alkylation of macromolecules and lipid peroxidation in the necrogenic effect of the toxin has been evaluated in in vivo experiments.

Keywords

Carbon Tetrachloride Lipoprotein Secretion Cellular Perturbation Golgi Fraction CCi4 Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    T.F. Slater, Hepatotoxicity of carbon tetrachloride: Fatty degeneration, in: “Free Radical Mechanisms in Tissue Injury,” J.R. Lagnado, ed., Pion Ltd, London (1972).Google Scholar
  2. 2.
    W.J. Brattin, E.A. Glende, Jr., and R.O. Recknagel, Pathological mechanisms in carbon tetrachloride hepatotoxicity, J. Free Rad. Biol. Med. 1:27 (1985).CrossRefGoogle Scholar
  3. 3.
    G. Poli, E. Chiarpotto, E. Albano, D. Cottalasso, G. Nanni, U.M. Marinari, A.M. Bassi, and M.U. Dianzani, Carbon tetrachloride-induced inhibition of hepatocyte lipoprotein secretion: Functional impairment of Golgi apparatus in the early phases of such injury, Life Sciences 36:533 (1985).PubMedCrossRefGoogle Scholar
  4. 4.
    E.A. Rodriguez Garay, and J. Pahissa Campa, Bilirubin metabolism in experimental liver injury, J. Lab. Clin. Med. 72:582 (1968).Google Scholar
  5. 5.
    G. Poli, E. Albano, F. Biasi, G. Cecchini, R. Carini, G. Bellomo, and M.U. Dianzani, Lipid peroxidation stimulated by carbon tetrachloride or iron in hepatocyte death: Protective effect of vitamin E, in: “Free Radicals in Liver Injury,” G. Poli, K.H. Cheeseman, M.U. Dianzani, and T.F. Slater, eds., IRL Press, Oxford (1985).Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Giuseppe Poli
    • 1
  • Elena Chiarpotto
    • 1
  • Fiorella Biasi
    • 1
  • Emanuele Albano
    • 1
  • Rita Carini
    • 1
  • Umberto M. Marinari
    • 2
  • Mario U. Dianzani
    • 1
  1. 1.Department of Experimental MedicineOncology of the UniversityTorinoItaly
  2. 2.Institute of General Pathology of the UniversityGenovaItaly

Personalised recommendations