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Reduction of Nitroheterocyclic Drugs by Ascorbate and Catecholamines: A Possible Mechanism for the Neurotoxicity of Nitroheterocyclic Drugs

  • D. N. Ramakrishna Rao
  • Ronald P. Mason
Part of the Basic Life Sciences book series (BLSC, volume 49)

Abstract

Nitroheterocyclic drugs such as 5-nitrofuran and 2- and 5-nitroimidazole derivatives are used as antimicrobial agents, some of which are selective for hypoxic cells.1 These compounds are also used as radiation sensitizers,2 and the 2-nitroimidazole derivative misonidazole was tested clinically. Unfortunately, a dose of 14 g/m2 needed to obtain sufficient tissue levels of this drug for sensitization produced a high incidence of peripheral neuropathy,3 hence this drug is of limited use.3 Nitrofurantoin and metronidazole also produce neuropathy.4,5 At lower doses nitrofurantoin is used as a urinary antiseptic,6 while metronidazole is used for amebic dysentery and for microbial infections of the vagina.7

Keywords

Electron Spin Resonance Electron Spin Resonance Spectrum Nitro Compound Mandelic Acid Semiquinone Radical 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • D. N. Ramakrishna Rao
    • 1
  • Ronald P. Mason
    • 1
  1. 1.Laboratory of Molecular BiophysicsNational Institute of Environmental Health SciencesResearch Triangle ParkUSA

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