Microinjection of Antioxidant Enzymes to Protect Cells from Oxygen Derived Free Radicals

  • Carine Michiels
  • José Remacle
Part of the Basic Life Sciences book series (BLSC, volume 49)


In recent years, there have been many reports on the protective effect of superoxide dismutase (SOD), catalase and glutathione peroxidase (Gpx) in preventing oxidative damages induced by a variety of toxic agents or occuring in pathological conditions . Despite all these works, the relative importance of each of these antioxidant enzymes is not yet well established. We undertook the present study in order to determine the respective efficiency of these three enzymes in protecting human fibroblasts against oxygen-derived free radicals generated either by oxygen or by nitrofurantoin.


Glutathione Peroxidase Oxygen Toxicity Human Diploid Fibroblast Free Radical Attack Enzyme Subunit 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Carine Michiels
    • 1
  • José Remacle
    • 1
  1. 1.Unité de Biochimie CellulaireFacultés Universitaires ND de la PaixNamurBelgium

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