Thiyl Free Radical Metabolites of Thiol Drugs and Glutathione

  • Kathryn T. Knecht
  • Carolyn Mottley
  • Ronald P. Mason
Part of the Basic Life Sciences book series (BLSC, volume 49)


Lactoperoxidase, a prototypical mammalian peroxidase, is part of an antimicrobial system found in secreted fluids.1 It is believed to act by oxidation of thiocyanate.2 Not surprisingly, it will also metabolize thiol moieties, oxidizing them to free radical intermediates. Thiol compounds are important in pharmacology and toxicology, and we have examined the production of highly reactive thiyl free radicals by this mechanism.


Ames Test North Carolina 27514 Thiol Compound Instrumental Condition Thiyl Radical 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Kathryn T. Knecht
    • 1
  • Carolyn Mottley
    • 2
  • Ronald P. Mason
    • 2
  1. 1.Curriculum in ToxicologyUniversity of North CarolinaChapel HillUSA
  2. 2.Laboratory of Molecular BiophysicsNational Institute of Environmental Health SciencesUSA

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