A cSOD-Null Mutant of Drosophila Confers Sensitivity to Paraquat and Reduced Longevity

  • J. P. Phillips
Part of the Basic Life Sciences book series (BLSC, volume 49)


Many widely accepted models of biological defense against toxic oxygen species invoke the active participation of superoxide dismutase as a front-line enzymatic defense (1). Such models rest primarily upon a variety of indirect observation and in vitro experiments; very few definitive in vivo experiments have been done. Consequently, we still do not have a clear understanding of the function of these enzymes in vivo. particularly as they relate to such complex biological phenomena as inflammation, mutagenesis, carcinogenesis and aging in higher eukaryotes.


Adult Lifespan Recessive Lethal Paraquat Toxicity Biological Defense Complex Biological Phenomenon 
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  1. 1.
    L.W. Oberley, “Superoxide Dismutase,” Vols. I-III, CRC Press, Boca Raton (1985).Google Scholar
  2. 2.
    J.E. Jellies, Identification of hexokinases and localization of a fructokinase and a tetrazolium oxidase locus in Drosophila melanogaster. Hereditas 67:291 (1972).Google Scholar
  3. 3.
    S.E. Campbell, A.J. Hilliker, and J.P. Phillips, Cytogenetic analysis of the cSOD microregion in Drosophila melanogaster. Genetics 112:205 (1986).PubMedGoogle Scholar
  4. 4.
    L.L. Smith, Paraquat toxicity, Phil. Trans. R. Soc. Lond. B 311:647 (1985).CrossRefGoogle Scholar
  5. 5.
    J.A. Farrington, M. Ebert, E.J. Land, and K. Fletcher, Bipyridylium quaternary salts and related compounds: Pulse radiolysis studies on the reaction of paraquat radical with oxygen, Biochim. Biophys. Acta 314:372 (1973).CrossRefGoogle Scholar
  6. 6.
    K.C. Kirkland and J.P. Phillips, Isolation and chromosomal localization of genomic DNA sequences coding for cytoplasmic superoxide dismutase from Drosophila melanogaster. Gene 61:415 (1987).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • J. P. Phillips
    • 1
  1. 1.Department of Molecular Biology and GeneticsUniversity of GuelphGuelphCanada

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