A cSOD-Null Mutant of Drosophila Confers Sensitivity to Paraquat and Reduced Longevity
Many widely accepted models of biological defense against toxic oxygen species invoke the active participation of superoxide dismutase as a front-line enzymatic defense (1). Such models rest primarily upon a variety of indirect observation and in vitro experiments; very few definitive in vivo experiments have been done. Consequently, we still do not have a clear understanding of the function of these enzymes in vivo. particularly as they relate to such complex biological phenomena as inflammation, mutagenesis, carcinogenesis and aging in higher eukaryotes.
KeywordsAdult Lifespan Recessive Lethal Paraquat Toxicity Biological Defense Complex Biological Phenomenon
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