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A cSOD-Null Mutant of Drosophila Confers Sensitivity to Paraquat and Reduced Longevity

  • J. P. Phillips
Part of the Basic Life Sciences book series (BLSC, volume 49)

Abstract

Many widely accepted models of biological defense against toxic oxygen species invoke the active participation of superoxide dismutase as a front-line enzymatic defense (1). Such models rest primarily upon a variety of indirect observation and in vitro experiments; very few definitive in vivo experiments have been done. Consequently, we still do not have a clear understanding of the function of these enzymes in vivo. particularly as they relate to such complex biological phenomena as inflammation, mutagenesis, carcinogenesis and aging in higher eukaryotes.

Keywords

Adult Lifespan Recessive Lethal Paraquat Toxicity Biological Defense Complex Biological Phenomenon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • J. P. Phillips
    • 1
  1. 1.Department of Molecular Biology and GeneticsUniversity of GuelphGuelphCanada

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