The Role of Glutathione Transferase in the Detoxication and Repair of Lipid and DNA Hydroperoxides
It is commonly accepted that cumulative effects of free radical damage to membranes and macromolecules are part of the aging process.1 Accumulation of damage takes place despite the presence in the cell of a number of protective mechanisms, including those which inhibit oxygen-centred free radical formation, detoxify active oxygen species and repair free radical damage. Peroxidation of membrane lipids and of DNA are two toxic consequences of the action of oxygen-centred free radicals,2 and in the present communication we discuss the significance of GSH transferase activity for their detoxication and repair. Attention will be drawn to a rarely studied isoenzyme from the rat, GSH transferase 5–5,3 which is very active in reducing DNA hydroperoxides and appears to be a major form in the nucleus.
KeywordsGlutathione Transferase Free Radical Damage Fatty Acid Hydroperoxide Methyl Uracil Phospholipid Hydroperoxide
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