Regional Cerebral Blood Flow Measurements Using the 133-Xenon Inhalation Method

  • G. Rodriguez
  • F. De Carli
  • G. Novellone
  • S. Marenco
  • G. Rosadini
Part of the NATO ASI Series book series (NSSA, volume 153)


The perfusional condition of the human brain has been studied extensively during the Last three decades, since the first measurements of cerebral blood flow (CBF) by the nitrous oxide method were reported (Kety & Schmidt, 1948).


cerebraL bLood fLow Regional Cerebral Blood Flow gLobaL cerebraL bLood fLow cerebraL bLood fLow Reduction cerebraL bLood fLow Increase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Ackerman RH, GouLiamos AD, Grotta JC, Correia JA, Chang JA, Fallick C, Taveras JM: Extracranial vascular disease and cerebral blood flow in patients with transient ischemic attacks. Acta Neurol Scand 60 (Suppl.72): 442 – 444, 1979.Google Scholar
  2. Andersen LA, Gormsen J: Platelet aggregation and fibrinolytic activity in transient cerebral ischemia. Acta Neurol Scand 55: 76 – 82, 1976.CrossRefGoogle Scholar
  3. Aoyagi M, Deshmukh VD, Meyer JS, Kawamura Y, Tagashira Y: Effect of beta-adrenergic blockade with propranolol on cerebral blood flow, autoregulation and CO2 responsiveness. Stroke 7: 291 – 295, 1976.CrossRefGoogle Scholar
  4. Arvigo F, Cossu M, Fazio Be Gris A, Pau A, Rodriguez G, Rosadini G,Sehrbundt Viale E, Siccardi D, Turtas S, Valsania V, Viale GL:Cerebral blood flow in minor cerebral contusion. Surg Neurol 24, 211 – 217, 1985.PubMedCrossRefGoogle Scholar
  5. Arvigo F, Cossu M, Pau A, Rodriguez G, Rosadini G, Sehrbundt Viale E, Siccardi D, Turtas S, Viale GL: Cerebral blood flow after mild head injury in adolescents. rCBF Bull 8: 167 – 170, 1984.Google Scholar
  6. Awad I, Little JR, Furlan AJ, Weinstein M: Correlaton of clinical and angiographic findings in brain ischemia with regional cerebral blood flow measured by the Xenon inhalation technique. Neurosurg 11: 1 – 5, 1982.CrossRefGoogle Scholar
  7. Barron SA, Jacobs L, Kinkel WR: Changes in size of normal lateral ventricles during aging determined by computerized tomography. Neurol (Minneap) 26: 1011 – 1013, 1976.CrossRefGoogle Scholar
  8. Berglund M, Nielsen S, Risberg J: Regional cerebral blood flow in a case of bromide psychosis. Arch Psych Nervenkr 223: 197 – 201, 1977.CrossRefGoogle Scholar
  9. Berglund M, Risberg J: Regional cerebral blood flow during alcohol withdrawal. Arch Gen Psych 38: 351 – 355, 1981.CrossRefGoogle Scholar
  10. Blauestein UW, Halsey JS, Wilson EM, Wills EL, Risberg J: 133—xenon method, analysis of reproducibility: some of its physiological implications. Stroke 8: 92 – 102, 1977.Google Scholar
  11. Bolmsjo M: Hemisphere cross—talk and signal overlapping in bilateral rCBF measurements using Xenon 133. Europ J Nucl Med 9: 1 – 5. 1984.CrossRefGoogle Scholar
  12. Brodersen P, Paulson OB, Bolwig TG, Rogon ZE, Rafaelson OJ, Lassen NA: Cerebral hyperemia in electrically induced epileptic seizures. Arch Neural 28: 334 – 338, 1973.CrossRefGoogle Scholar
  13. Brody H: Organization of the cerebral cortex III:a study of aging in the human cerebral cortex. J Comp Neurol 102: 511 – 516, 1955PubMedCrossRefGoogle Scholar
  14. Brown MM, Wade JPH, Marshall J: Fundamental importance of arterial oxygen content in the regulation of cerebral blood flow in man. Brain 108: 8193, 1985.CrossRefGoogle Scholar
  15. Bruce DA, Langfitt TW, Miller JD, Schutz H, Valpalahti MP, Stanck A, Goldberg HI: Regional cerebral blood flow,intracranial pressure and brain metabolism in comatose patients. J Neurosurg 38: 131 – 144, 1973.PubMedCrossRefGoogle Scholar
  16. Burke AM, Younkin D, Gordon J, Goldberg H, Graham T, Kushner M, Obrist W, Jaggi J, Rosen M, Reivich M:Changes in cerebral blood flow and recovery from acute stroke. Stroke 17: 173 – 178, 1986.PubMedCrossRefGoogle Scholar
  17. Collins RC, Kennedy C, Sokoloff L, Plum F: Metabolic anatomy of focal motor seizures. Brain Res 150: 536 – 542, 1976.Google Scholar
  18. Cossu M, Cabri M, Decarli F, Montano VF, Rodriguez G, Siccardi A, Traverso R, Rosadini G: Regional cerebral blood flow: normal values in healthy volunteers obtained by a 32 probes 133—Xenon inhalation system. Boll Soc Ita Biol Sperim 43: 766 – 772, 1982.Google Scholar
  19. Couch JR, Hassanein RS: Platelet aggregation,stroke and transiet ischemic attack in middle-aged elderly patients. Neurol 26: 888 – 895, 1976.CrossRefGoogle Scholar
  20. Dandona P, James IM, Newbury PA, Woollard ML, Beckett AG: Cerebral blood flow in diabetes mellitus: evidence of abnormal cerebrovascular reactivity. Br Med J 2: 325 – 326, 1978.PubMedCrossRefGoogle Scholar
  21. Dandona P, James IM, Woollard ML, Newbury P, Beckett AG: Instability of cerebral blood-flow in insulin-dependent diabetics. Lancet 2: 1203 – 1205, 1979.PubMedCrossRefGoogle Scholar
  22. Dastur DK: Cerebral blood flow and metabolism in normal human aging, pathological aging and senile dementia. J Cer Blood Flow Metab 5: 1 – 9, 1985.CrossRefGoogle Scholar
  23. Davis SM, Ackerman RH, Correia JA, Alpert NM, Chang J, Buonanno R, Kelley RE, Rosner B, Taveras JM: Cerebral blood flow and cerebrovascular CO2 reactivity in stroke-age normal controls. Neurology, 33: 391 – 399, 1983.PubMedCrossRefGoogle Scholar
  24. Deshmukh VD, Meyer JS: Non invasive measurements of regional cerebral blood flow in man. SP medical and scientific books, a division of Spectrum Publications Inc New York, London, 1978.Google Scholar
  25. Deutsch G, Papanicolaou AC, Eisenberg HM, Loring DW, Levin HS: CBF gradient changes elicited by visual stimulation and visual memory tasks. Neuropsychologia 24: 283 – 287, 1986.PubMedCrossRefGoogle Scholar
  26. Donley RF, Sundt TM, Anderson RE, Sharbrough FW:Blood flow measurements and the “look through” artifact in focal cerebral ischemia.Stroke, 6: 121 – 131, 1975.Google Scholar
  27. Fang HCH: Observations on aging characteristics of cerebral blood vessels, macroscopic and microscopic features. In: Terry ed.: Neurobiology of aging, vol. 3. Raven Press, New York, pp. 155 – 166; 1976.Google Scholar
  28. Fieschi C, Battistini N, Beduschi A: Regional Cerebral Blood Flow and intraventricular pressure in acute head injuries. J Neurol Neurosurg Psychiat 37: 1378 – 1388, 1974.PubMedCrossRefGoogle Scholar
  29. Fieschi C, DesRosier M: Cerebral blood flow measurements in stroke.In: R.Russel ed.: Cerebral Arterial Disease. Churchill Livinstone, Edimburgh, pp. 85–106; 1976.Google Scholar
  30. Forster A, Juge 0, Morel D: Effects of Midazolam on cerebral hemodynamics and cerebral vasomotor responsiveness to carbon dioxide. J Cer Blood Flow Metab 3: 246 – 249, 1983.CrossRefGoogle Scholar
  31. Fujishima M, Nishimaru K, Omae T: Long-term prognosis in stroke related to cerebral blood flow-Stroke 8: 680 – 683, 1977.Google Scholar
  32. Gaab MR, Brawanski A, Bockhorn J, Haubitz I, Rode CP, Maximilian VA: Calcium antagonism: a new therapeutic principle in stroke and cerebrovascular vasospasm? rCBF Bulletin 3: 47 – 51, 1982.Google Scholar
  33. Greitz TVB: Effect of brain distension on cerebral circulation. Lancet 1, 863 – 865, 1969.PubMedCrossRefGoogle Scholar
  34. Greitz TVB, Grepe AOL, Kalmer MSF: Pre-and post-operative evaluation of cerebral blood flow in low pressure hydrocephalus. J Neurosurg 31: 644 – 651, 1969.PubMedCrossRefGoogle Scholar
  35. Grubb RI, Raichle ME, Eichling JO, Ter-Pogossian MM: The effects of changes in PaCO2 on cerebral blood volume, blood flow and vascular mean transit time. Stroke 5: 630 – 639, 1974.PubMedCrossRefGoogle Scholar
  36. Gur RC, Gur RE, Obrist WD, Hungerbuhler JP, Younkin D, Rosen AD, Skolnick BE, Reivich M: Sex and handedness differences in cerebral blood flow during rest and cognitive activity. Science 217: 659 – 661, 1982PubMedCrossRefGoogle Scholar
  37. Gur RC, Reivich M: Cognitive task effects on hemispheric blood flow in humans: evidence for individual differences in hemispheric activation. Brain and Language 9: 78 – 92, 1980.PubMedCrossRefGoogle Scholar
  38. Gustafson L, Risberg J, Johanson M, Fransson M, Maximilian VA: Effects of piracetam on regional cerebral blood flow and mental functions in patients with organic dementia. Psychopharmacology 56, 115 – 117, 1978.PubMedCrossRefGoogle Scholar
  39. Gustafson L, Risberg J, Silfverskiold P: Cerebral blood flow in dementia and depression. Lancet 1: 275, 1981.PubMedCrossRefGoogle Scholar
  40. Hagstadius S, Risberg J: The effects of normal aging in man on rCBF during resting and functional activation. rCBF Bull 6: 116 – 120, 1983.Google Scholar
  41. Halsey JH, Blauenstein UW, Wilson EM, Wills EL: The rCBF response to speaking in normal subjects, and the time course of alterations in patients recovering from Left and right hemisphere stroke. Neurol 27: 351 – 352, 1977.Google Scholar
  42. Halsey J, Blauenstein U, Wilson E, Wills E: Regional cerebral blood flow comparison of right and left hand movement. NeuroL 29: 21 – 28, 1979.CrossRefGoogle Scholar
  43. Halsey J, Blauenstein U, Wilson E, Wills E: Brain activation in the presence of brain damage. Brain and language 9: 47 – 60, 1980a.PubMedCrossRefGoogle Scholar
  44. Halsey JH, Blauenstein UW, Wilson EM, Wills E: rCBF activation in a patient with right homonymous hemianopia and alexia without agraphia. Brain & Language 9: 137 – 140, 1980b.CrossRefGoogle Scholar
  45. Halsey JH, Nakai K, Wariyar B: Sensitivity of rCBF to focal lesions. Stroke 12: 631 – 635, 1981.PubMedCrossRefGoogle Scholar
  46. Hartmann A: Prolonged disturbances of regional cerebral blood flow in transient ischemic attacks. Stroke 16: 932 – 939, 1985.PubMedCrossRefGoogle Scholar
  47. Hayashi M, Kobayashi H, Kawano H, Yamamoto S, Maeda T: Cerebral blood flow and ICP patterns in patients with communicating hydrocephalus after aneurysm rupture. J Neurosurg 61: 30 – 36, 1984.PubMedCrossRefGoogle Scholar
  48. Hazelrig JB, Katholi CR, Blauenstein UW, Halsey JH, Wilson EM, Wills EL: Total curve analysis of regional cerebral blood flow with 133-Xe inhalation: Description of method and values obtained with normal volounteers.IEEE Trans on Biomed Eng 28: 609 – 616, 1981.Google Scholar
  49. Heilbrun MP, Olesen J, Lassen NA: Regional cerebral blood flow studies in subarachnoid hemorrhage. J Neurosurg 37: 36 – 44, 1972.PubMedCrossRefGoogle Scholar
  50. Heilbrun MP, Reichman OH, Anderson RE, Roberts TS: Regional cerebral blood flow in studies following superficial temporal middle cerebral artery anastomosis. J Neurosurg 43: 706 – 716, 1975.PubMedCrossRefGoogle Scholar
  51. Heiss WD, Zeiler K,Havelec L, Reisner T, Bruck J:Long-term prognosis in stroke related to cerebral blood flow. Arch Neurol 34: 671 – 676, 1977.PubMedCrossRefGoogle Scholar
  52. Hougaard K, Oikawa T, Sveinsdottir E, Skinhoj E, Ingvar DH, Lassen NA: Regional cerebral blood flow in focal cortical epilepsy. Arch Neurol 33: 527 – 535, 1976.PubMedCrossRefGoogle Scholar
  53. Ingvar DH: “Hyperfrontal” distribution of the cerebral grey matter flow in resting wakefulness: on the anatomy of the conscious state. Acta Neurol Scand 60:21–25, 1979.CrossRefGoogle Scholar
  54. Ingvar DH: Measurements of regional cerebral blood flow and metabolism in psycopathological states. Eur Neurol 20: 294 – 296, 1981.PubMedCrossRefGoogle Scholar
  55. Ingvar DH: Mental illness and regional brain metabolism. TINS 5: 199 – 203, 1982.Google Scholar
  56. Ingvar DH, Risberg J: Increase of regional cerebral blood flow during mental effort in normals and in patients with focal brain disorders. Exper Brain Research 3: 195 – 211, 1967.Google Scholar
  57. Ingvar DH, Schwartz MS: The cerebral blood flow in low pressure hydrocephalus. In Lundberg N, Porten U, Brock M (eds): Intracranial pressure II.New York, Springer Verlag, 153 – 156, 1975.CrossRefGoogle Scholar
  58. Ingvar DH, Philipson L: Distribution of cerebral blood flow in the dominant hemisphere during motor ideation and motor performance. Ann Neurol 2: 230 – 237, 1977.PubMedCrossRefGoogle Scholar
  59. Ishihara N, Meyer JS, Deshmukh VD, Hsu MC: Non-invasive measurements of regional cerebral blood flow (rCBF) in man. Normal values, effects of age, cerebral dominance and activation. Neurol 20: 401, 1977.Google Scholar
  60. Jablonski T, Prohovnik I, Risberg J, Stahl KE, Maximilian VA, Sabsay E: Fourier analysis of 133-Xe inhalation curves: Accuracy and sensitivity. Acta Neurol Scand 60, Suppl. 72: 216 – 217, 1979.Google Scholar
  61. Jarret F, Polcyn R, Levin A, McCormick D: The use of hypercapnia in the study of regional cerebral blood flow abnormalities with 133-Xe. J Surg Research 32: 104 – 109, 1982.CrossRefGoogle Scholar
  62. Jensen KB, Hoedt-Rasmussen K, Sveinsdottir E, Stewart BM, Lassen NA: Cerebral blood flow evaluated by inhalation of 133-Xenon and extracranial recording: a methodological study. Clin Sci 30: 485 – 494, 1966.PubMedGoogle Scholar
  63. Keating EG, Ewing J, Sheehe P: The clinical uselfulness of inhalation rCBF measurements in patients with completed stroke. In:Harper AM, Jennet WB, Miller JD, Rowan RO eds: Blood Flow and Metabolism in the Brain. Churchill Livingstone, Edimburgh, pp. 823–824, 1975.Google Scholar
  64. Kety SS, Schmidt CF: The nitrous oxide method for the quantitative determination of cerebral blood flow in man: Theory, procedure and normal values. J Clin Investig 27: 476 – 483, 1948.CrossRefGoogle Scholar
  65. Knopman DS, Rubens AB, Klassen AC, Meyer MW, Niccum N: Regional cerebral blood flow patterns during verbal and non verbal auditory activation. Brain & Language 9: 93 – 112, 1980.CrossRefGoogle Scholar
  66. Kubota K, Yamaguchi T, Abe Y, Fujiwara T, Hatazawa J, Matsuzawa T: Effects of smoking on regional cerebral blood flow in neurologically normal subjects. Stroke 14: 720 – 724, 1983.PubMedCrossRefGoogle Scholar
  67. Lassen NA: Normal average value of cerebral blood flow in younger adults is 50/ml/100 g/min. J Cer Blood Flow Metab 3: 347 – 349, 1985.CrossRefGoogle Scholar
  68. Lassen NA, Agnoli A: The upper limit of autoregulation of cerebral blood flow on the pathogenesis of hypertensive encephalopathy. Scand J Clin Lab Invest 30: 113, 1972.PubMedCrossRefGoogle Scholar
  69. Lassen NA, Ingvar DH: Radioisotopic assessment of regional cerebral blood flow. In: Progress in nuclear medicine. Basel:Karger Vol I pp:376–409, 1972Google Scholar
  70. Lavy S, Melamed E, Potnoy Z, Carmon A: Inter—ictal regional cerebral blood flow in patients with partial seizures. Neural 26: 418 – 422, 1976.Google Scholar
  71. Lavy S, Melamed E, Cooper G, Bentin S, Rinot Y: Regional cerebral blood flow in patients with Parkinson’s disease. Arch Neurol 36: 344 – 348, 1979.PubMedCrossRefGoogle Scholar
  72. Leli DA, Hannay HJ, Falguot JC, Katholi CR, Halsey JH: Age effects on focal cerebral blood flow changes produced by a test of right—left discrimination. Neuropsychologia 21: 525 – 533. 1983.PubMedCrossRefGoogle Scholar
  73. Mallet BL, Veall. N: The measurement of regional cerebral clearance rates in man using Xenon-133 inhalation and extracranial recording. Clin Sci 29: 179 – 191, 1965.Google Scholar
  74. Mathew NT, Meyer JS, Hartmann A, Ott EO: Abnormal cerebrospinal fluid blood flow dynamics. Implications in diagnosis, treatment, and prognosis in normal pressure hydrocephalus. Arch Neural 32, 657 – 664, 1975.CrossRefGoogle Scholar
  75. Mathew RJ, Duncan GC, Weinman ML, Barr DL:Regional cerebral blood flow in schizophrenia. Arch Gen Psych 39: 1121 – 1124, 1982.CrossRefGoogle Scholar
  76. Mathew RJ, Wilson WH: Caffeine—induced changes in cerebral circulation. Stroke 16: 814 – 817, 1985a.PubMedCrossRefGoogle Scholar
  77. Mathew RJ; Wilson WH: Dextroamphetamine—induced changes in regional cerebral blood flow. Psycophar 87: 298 – 302, 1985b.CrossRefGoogle Scholar
  78. Matsuda H, Maeda T, Yamada M, Gui LX, Hisada K: Age—matched normal values and topographic maps for regional cerebral blood flow measurements by 133—Xe inhalation. Stroke 15: 336 – 342, 1984.PubMedCrossRefGoogle Scholar
  79. Maximilian VA: Cortical blood flow asymmetries during monoaural verbal stimulation. Brain and Language 15: 1 – 11, 1982.PubMedCrossRefGoogle Scholar
  80. Maximilian VA, Prohovnik I, Risberg J, Hakansson K: Regional cerebral blood flow changes in the Left cerebral hemisphere during word pair learning and recall. Brain and Language 6: 22 – 31, 1978.PubMedCrossRefGoogle Scholar
  81. Maximilian VA, Prohovnik I, Risberg J: Cerebral hemodynamic response to mental activation in normo and hypercapnia. Stroke 11: 342 – 347, 1980.PubMedCrossRefGoogle Scholar
  82. Maximilian VA, Rosadini G, Rodriguez G, Montano VF, Arvigo F, Sannita WG: Impaired cerebral perfusion in asymptomatic boxers. J Cer Blood Flow Metabol 5, Suppl. 1, 27 – 28, 1985.Google Scholar
  83. McHenry LC, Merory J, Bass E, Stump DA, Williams R, Witcofski R, Howard G, Toole JF: Xenon-133 inhalation method for regional cerebral blood flow measurements:normal values and test—retest results. Stroke 9, 396 – 399, 1978.PubMedCrossRefGoogle Scholar
  84. McHenry LC, Stump DA, Howard G, Novack TT, Bivins DH, Nelson AO: Comparison of the effects of intravenous papaverine hydrochloride and oral pavabid hp capsulets on regional cerebral blood flow in normal individuals. J Cer Blood Flow Metabol 3: 442 – 447, 1983.CrossRefGoogle Scholar
  85. Melamed E, Larsen B: Regional cerebral blood flow during voluntary conjugate eye movements in man. Acta Neurol Scand 56,Suppl. 64: 530 – 531, 1977.Google Scholar
  86. Melamed E, Lavy S, Bentin S, Cooper G, Rinot Y: Reduction in regional cerebral blood flow during normal aging in man. Stroke 11: 31 – 35, 1980.PubMedCrossRefGoogle Scholar
  87. Meric P, Luft A, Seylaz J, Mamo H: Analysis of reproducibility and sensitivity of atraumatic measurements of regional cerebral blood flow in cerebrovascular diseases. Stroke 14: 82 – 87, 1983.PubMedCrossRefGoogle Scholar
  88. Meyer JS, Gotoh F, Favale E: Cerebral metabolism during epileptic seizures in man. Electroenc Clin Neurophysiol 21: 10 – 22, 1966.CrossRefGoogle Scholar
  89. Meyer JS, Ishihara N, Deshmukh VD, Naritomi H, Sakai F, Hsu M, Pollack P: Improved method for noninvasive measurement of regional cerebral blood flow by 133-Xenon inhalation. Part I: Description of the method and normal values obtained in healthy volunteers. Stroke 9: 195 – 205, 1978a.PubMedCrossRefGoogle Scholar
  90. Meyer JS, Rogers RL, Mortel KF: Prospective analysis of Long term control of mild hypertension on cerebral blood flow. Stroke 16: 985 – 990, 1985.PubMedCrossRefGoogle Scholar
  91. Meyer JS, Sakai F, Naritomi H, Grant P: Normal and abnormal patterns of cerebrovascular reserve tested by 133-Xe inhalation. Arch Neurol 35: 350 – 359, 1978b.PubMedCrossRefGoogle Scholar
  92. Meyer JS, Sakai F, Yamaguchi F, Yamamoto M, Shaw T: Regional changes in cerebral blood flow during standard behavioral activation in patients with disorders of speech and mentation compared to normal volunteers. Brain & Language 9: 61 – 77, 1980.CrossRefGoogle Scholar
  93. Mies G, Auer LM, Ebhardt G, Traupe H, Heiss WD: Flow and neuronal density in tissue surrounding chronic infarction. Stroke 14: 22 – 27, 1983.PubMedCrossRefGoogle Scholar
  94. Mosmans PCM,Veering MM, Jonkman EJ: ISI values and interhemispheric differences in patients with ischemic cerebrovascular disease; correlations with clinical and angiographic findings. Stroke 17: 58 – 64, 1986.CrossRefGoogle Scholar
  95. Naritomi H, Meyer JS, Deshmukh VD, Pollack P: Non-invasive measurements of regional cerebral blood flow in TIA’s and stroke due to carotid and vertebrobasilar disease. Acta Neurol Scand 56 (Suppl 64): 2514 – 2515, 1977.Google Scholar
  96. Naritomi H, Meyer JS, Sakai F, Yamaguchi F, Shaw T: Effects of advancing age on regional cerebral blood flow. Arch Neurol 36: 410 – 416, 1979.PubMedCrossRefGoogle Scholar
  97. Nilsson A, Risberg J, Johanson M, Gustafson L: Regional changes of cerebral blood flow during haloperidol therapy in patients with paranoid symptoms. Acta Neurol Scand 56 (SUppl 64): 478 – 479, 1977.Google Scholar
  98. Nordstrom CH, Sjesjo BK: Regulation of brain energy metabolism under normoxic and hypoxic conditions. Brain Heart Infarct, Berlin, Springer Verlag, pp 33 – 40, 1977.CrossRefGoogle Scholar
  99. Norrving B, Nilsson B, Risberg J: rCBF in patients with carotid occlusion: resting and hypercapnic flow related to collateral pattern. Stroke 13, 155 – 162, 1982.PubMedCrossRefGoogle Scholar
  100. O’Brien MD:Cerebral blood changes in migraine. Headache 10, 139–143, 1971.PubMedCrossRefGoogle Scholar
  101. Obrist WD, Dolinskas CA, Gennarelli TA, Zimmerman RA: Relation of cerebral blood flow to CT scan in acute head injury. In: Popp AJ, Bourke RS, Nelson LR, Kimerberg HK (eds): Neural Trauma. New York, Raven Press, 41 – 50, 1979.Google Scholar
  102. Obrist WD, Silver D, Wilkinson WE, Harel D, Heyman A, Wang HS: The 133 Xenon inhalation method: Assessment of rCBF in carotid endarterectomy. In: Langfitt TW, McHenry MR, Wollman H (eds) Cerebral circulation and metabolism. New York, Springer Verlag, 398 – 401, 1975a.CrossRefGoogle Scholar
  103. Obrist WD, Thompson HK, King CH, Wang HS: Determination of regional cerebral blood flow by inhalation of 133-Xenon. Circ Res 20: 124–135, 1967.PubMedCrossRefGoogle Scholar
  104. Obrist WD, Thompons HK, Wang HS, Wilkinson WE:Regional cerebral blood flow estimated by Xenon 133 inhalation. Stroke 6: 245 – 256, 1975b.PubMedCrossRefGoogle Scholar
  105. Obrist WD, Wilkinson WE: The non invasive 133-Xenon method: evaluation of CBF indices. In: Moosy J, Reinmuth Om (eds),Cerebrovascular disease 12th Princeton Conference, Raven Press, New York, p 119 – 124, 1981.Google Scholar
  106. Oikawa T, Kanaya H: Regional cerebral blood flow activated with photic stimulation in focal cortical epilepsy. In: Cerebral blood flow, metabolism and epilepsy. Baldy-Moulinier M, Ingvar DH, Meldrum BS (eds).John Libbey, London, pp 26 – 32, 1983.Google Scholar
  107. Olesen J: Controlateral focal increase of cerebral blood flow in man during arm work. Brain 94: 635 – 646, 1971.PubMedCrossRefGoogle Scholar
  108. Olesen J: Cerebral blood flow methods for measurement regulation, effects of drugs and changes in disease. Copenhagen:Fadls Forlag,pp: 11 – 18, 1974.Google Scholar
  109. Olesen J: Migraine and regional cerebral blood flow. TINS 8: 318 – 321, 1985.Google Scholar
  110. Otsuki Y, Kondo T, Shio H Kameyama M, Koyama T: Platelet aggregability in cerebral trombosis analysed for vessel stenosis. Stroke 14: 368 – 371, 1983.PubMedCrossRefGoogle Scholar
  111. Overgaard J: The distribution of cerebral blood flow values in traumatic coma.In: Grossman RG, Gildemberg PL (eds): Head Injury: basic and clinical aspects. New York, Raven Press, 239–245, 1982.Google Scholar
  112. Overgaard J, Tweed WA: Cerebral circulation after head injury. Part 1. cerebral blood flow and its regulation after closed head injury with emphasis on clinical correlations. J Neurosurg 41: 531 – 541, 1974.PubMedCrossRefGoogle Scholar
  113. Overgaard, Tweed WA: Cerebral circulation after head injury. Part 2: Effects of traumatic brain edema. J Neurosurg 45: 292 – 300, 1976.PubMedCrossRefGoogle Scholar
  114. Overgaard J, Tweed WA: Cerebral circulation after head injury. Part 4: Functional anatomy and boundary-zone flow deprivation in the first week of traumatic coma. J Neurosurg 59: 439 – 446, 1983.PubMedCrossRefGoogle Scholar
  115. Potchen EJ, Davis DO, Wharton T: Regional cerebral blood flow in man. I. A study of the Xenon 133 washout method. Arch Neurol 20: 378 – 383, 1969.PubMedCrossRefGoogle Scholar
  116. Prohovnik I, Hakansson K, Risberg J: Observations on the functional significance of regional cerebral blood flow in resting normal subjects. Neuropsychologia 18: 203 – 217, 1980.PubMedCrossRefGoogle Scholar
  117. Prohovnik I, Knudsen E, Risberg J: Accuracy of models and algorithms for determination of fast compartment flow by noninvasive 133-Xe clearance. In: Magistretti P (ed): Functional radionuclide imaging of the brain, New York,Raven press,pp 87 – 116, 1983a.Google Scholar
  118. Prohovnik I, Risberg J, Hagstadius S,: Temporal lobe activation by verbal memorization studied with 133-Xe inhalation rCBF. J Cer Blood Flow Metab 3: (Suppl 1): 276 – 277, 1983b.Google Scholar
  119. Raichle ME, Grubb RB, Gado MH, Eichling JO, Ter-Pogossian MM: Correlation between regional cerebral blood flow and oxidative metabolism. Arch Neurol 33: 523 – 526, 1976.PubMedCrossRefGoogle Scholar
  120. Rao NS, Ali ZA, Omar HM, Halsey JH: regional cerebral blood flow in acute stroke:preliminary experience with the 133-Xenon inhalation method. Stroke 5: 8 – 12, 1974.PubMedCrossRefGoogle Scholar
  121. Reivich M, Obrist WD, Slater R, Greenbeerg J, Goldberg HI: A comparison of the Xenon-133 intracarotid injection and inhalation technique for measuring regional cerebral blood flow. In: Harper AM, Jennet WB, Miller JD, Rowan JO (eds): Blood flow and metabolism in the brain. Edimburgh, Churchill Livingstone, 1975.Google Scholar
  122. Risberg J: Regional cerebral blood flow measurements by 133-Xe inhalation methodology and applications in neuropsychology and psychiatry. Brain and Language 9: 9 – 34, 1980.PubMedCrossRefGoogle Scholar
  123. Risberg J: Regional cerebral blood flow in neuropsycology. Neuropsycologia 24: 135 – 140, 1986.CrossRefGoogle Scholar
  124. Risberg J, Ali Z, Wilson EM, Wills EL, Halsey JH: Regional cerebral blood flow by 133-Xenon inhalation. Preliminary evaluation of an initial slope index in patients with unstable flow compartments. Stroke 6: 142–148, 1975a.Google Scholar
  125. Risberg J, Gustafson L: 133-Xe cerebral blood flow in dementia and in neuropsychiatry research. In: Magistretti P (ed): Functional radionuclide imaging of the brain, New York, Raven Press, pp. 151 – 160, 1983.Google Scholar
  126. Risberg J, Hagstadius S: Effects on the regional cerebral blood flow of long-term exposure to organic solvents. Acta Psychiat Scand 67 (Suppl. 303): 92 – 99, 1983.Google Scholar
  127. Risberg J, Halsey JH, Wills EL, Wilson EM: Hemispheric specialisation in normal man studied by bilateral measurements of the regional cerebral blood flow. A study with the 133-Xenon inhalation technique. Brain 98: 511 – 524, 1975b.PubMedCrossRefGoogle Scholar
  128. Risberg J, Maximilian AV, Prohovnik I: Changes of cortical activity patterns during habituation to a reasoning test. Neuropsychologia 15: 793 – 798, 1977a.PubMedCrossRefGoogle Scholar
  129. Risberg J, Prohovnik I: rCBF measurements by 133-Xenon inhaLation: Recent methodological advances. Prog in Nucl Med 7: 70 – 81, 1981.Google Scholar
  130. Risberg J, Prohovnik I: Cortical processing of visual and tactile stimuli studied by non-invasive rCBF measurements. Human Neurobiol 2: 5 – 10, 1983.Google Scholar
  131. Risberg J, Uzzell BP, Obrist WD: Spectrum subtraction technique for minimizing extracraniaL influence on cerebral blood flow measurements by 133-Xenon inhalation. Stroke 8: 380 – 382, 1977b.PubMedCrossRefGoogle Scholar
  132. Rodriguez G, Arvigo F, Marenco S, Nobili F, Romano P, Sandini G, Rosadini G: Regional cerebral blood flow in essential hypertension: data evaluation by a mapping system. Stroke, in press.Google Scholar
  133. Rodriguez G, Ferrillo F, Montano VF, Rosadini G, Sannita WG: Regional cerebral blood flow in boxers. Lancet 2 (8354): 858, 1983a.PubMedCrossRefGoogle Scholar
  134. Rodriguez G, Rosadini G: Flussimetria ematica cerebrale regionale con metodo non invasivo. In: Moglia A, Arrigo A (eds): Compromissione e ripresa della motilita’: correlati neurofisiologici. EMI-RAS Pavia pp:219–240, 1984.Google Scholar
  135. Rodriguez G, Testa R, Rosadini G, Arvigo F, Celle G, Gris A, Sannita WG, Sukkar GS, Traverso R: Reduction of regional cerebral blood flow in subclinical hepatic encephalophaty. IRCS Medical Science 11: 763, 1983b.Google Scholar
  136. Rogers RL, Meyer JS, Shaw TG, Mortel KF, Hardenberg JP, Zaid RR: Cigarette smoking decreases cerebral blood flow suggesting increased risk for stroke. JAMA 250: 2796 – 2800, 1983.PubMedCrossRefGoogle Scholar
  137. Roland PE: Cortical organization of voluntary behaviour in man. Human Neurobiol 4: 155 – 167, 1985.Google Scholar
  138. Roland PE, Larsen B: Focal increase of cerebral blood flow during stereognostic testing in man. Arch Neurol 33: 551 – 558, 1976.PubMedCrossRefGoogle Scholar
  139. Roland PE, Larsen B, Lassen NA, Skinhoj E: Supplementary motor area and other cortical areas in organization of voluntary movements in man. J Neurophysiol 43: 118 – 136, 1980a.PubMedGoogle Scholar
  140. Roland PE, Skinhoj E, Lassen NA, Larsen B: Different cortical areas in man in organization of voluntary movements in extrapersonal space. J Neurophysiol 43: 137 – 150, 1980b.PubMedGoogle Scholar
  141. Rosadini G, Ferrillo F, Rodriguez G, Sannita WG, Arvigo F: rCBF and quantitative EEG correlations in epileptic patients. In: Cerebral blood flow,metabolism and epilepsy. Baldy-Moulinier M,Ingvar DH, Meldrum BS (eds).John Libbey, London, pp 26 – 32, 1983.Google Scholar
  142. Rosadini G, Rodriguez G, Sandini G, Arvigo F, De Carli F, Romano P: A rCBF statistical-mapping system:data management in stroke patients. Acute Brain Ischemia 1985. Siena 11–14 sept. 1985.Google Scholar
  143. Rosadini G, Rodriguez G, Sannita WG, Arvigo F: Correlations between rCBF and computerized EEG in temporal lobe epilepsy. Acta Neurochirurgica Suppl 33: 119 – 122, 1984.Google Scholar
  144. Rosestein J, Wang AD-J, Symon L, Suzuki M: Relationship between hemispheric cerebral blood flow,central conduction time,and clinical grade in aneurysmal subarachnoid hemorrhage. J Neurosurg 62: 25 – 30, 1985.CrossRefGoogle Scholar
  145. Sakai F, Meyer JS: Regional cerebral hemodinamics during migraine and cluster headache measured by the 133-Xe inhalation method. Headache 18: 122 – 132, 1978.PubMedCrossRefGoogle Scholar
  146. Sakai F, Meyer JS, Naritomi H, Hsu M: Regional cerebral blood flow and EEG in patients with epilepsy. Arch Neurol 35: 648 – 657, 1978.PubMedCrossRefGoogle Scholar
  147. Sandini G, Rodriguez G, Romano P, Rosadini G: Topographic mapping of rCBF data: techniques and statistical comparisons. In: Pet and Nmr: new perspectives in neuroimaging and clinical neurochemistry. Battistin L (ed): Alan R Liss Inc, New York in press.Google Scholar
  148. Scheinberg P, Meyer JS, Reivich M, Sundt TM, Waltz AG: XIII Cerebral circulation and metabolism in stroke. Cerebral circulation and metabolism in Stroke study group. Stroke 7: 212 – 234, 1976.PubMedCrossRefGoogle Scholar
  149. Schmiedek P, Gratzl 0, Spetzler R Steinhoff H, Enzenbach R, Brendel W, Marguth F: Selection of patients for extracranial by-pass surgery based on rCBF measurements. J Neurosurg 44: 303 – 312, 1976.PubMedCrossRefGoogle Scholar
  150. Shaw TG, Mortel KF, Meyer JS, Rogers RL, Hardenberg J, Cutaia MM: Cerebral blood flow changes in benign aging and cerebrovascular disease. Neurology 34: 855 – 862, 1984.PubMedCrossRefGoogle Scholar
  151. Sheppard G, Gruzelier J, Manchanda R, Hirsch SR, Wise R, Frackowiak R, Jones T: 150 positron emission tomographic scanning in predominantly never-treated acute schizophrenic patients. Lancet 2:(8365–8366):1448–1452, 1983.PubMedCrossRefGoogle Scholar
  152. Simard D, Paulson OB:Cerebral vasomotor paralysis during migraine attack. Arch Neurol 29: 207 – 209, 1973.PubMedCrossRefGoogle Scholar
  153. Skinhoj E: Hemodinamic studies within the brain during migraine. Arch Neurol 29: 95 – 98, 1973.PubMedCrossRefGoogle Scholar
  154. Slater R, Reivich M, Goldberg H, Banka R, Grenberg J: Diaschisis with cerebral infarction. Stroke 8: 684 – 690, 1977.PubMedCrossRefGoogle Scholar
  155. Smith CB: Aging and changes in cerebral energy metabolism. TINS 6: 203 – 208, 1984.Google Scholar
  156. Strandgaard S: Autoregulation of regional cerebral blood flow in hypertensive patients. Circulation 53, 720 – 727, 1976.PubMedCrossRefGoogle Scholar
  157. Stump DA, Williams R: The noninvasive measurement of regional cerebral circulation. Brain & Language 9: 35 – 46, 1980.CrossRefGoogle Scholar
  158. Takano T: A development of a soft ware system for generating a functional image of regional cerebral blood flow and its clinical application to the patients with cerebrovascular disease. Jap J Nucl Med (Tokyo) 16: 201 – 215, 1979.Google Scholar
  159. Tanahashi N, Meyer JS, Rogers RL, Kitagawa Y, Mortel KF, Kandula P, Levinthal R, Rose J: Long-term assessment of cerebral perfusion following STA-MCA by-pass in patients. Stroke 16: 85 – 91, 1985.PubMedCrossRefGoogle Scholar
  160. Thomas M, Hennerici M, Marshall J: Cerebral blood flow after carotid occlusion and extracranial-intracranial bypass. J Neurol Neurosurg Psychiat 47: 148 – 152, 1984.PubMedCrossRefGoogle Scholar
  161. Thomlinson BE, Blessed G, Roth M:Observations on the brains of non demented old people. J Neurol Sci 7: 331 – 356, 1968.CrossRefGoogle Scholar
  162. Tohgi H, Yamanouchi H, Murakami M, Kameyama M: Importance of the hematocrit as a risk factor in cerebral infarction. Stroke 9: 369 – 374, 1978.PubMedCrossRefGoogle Scholar
  163. Traub M, Shapiro AP, Dujovny M, Nelson D: cerebral blood flow changes with diuretic therapy in elderly subjects with systolic hypertension. Clin Exper Hyper A4 (7): 1193 – 1201, 1982.CrossRefGoogle Scholar
  164. Touchon J, Valmier J, Baldy-Moulinier M: Regional cerebral blood flow in temporal lobe epilepsy: inter-ictal studies.In: Cerebral blood flow Baldy-Moulinier M,Ingvar DH, Meldrum BS (eds).John Libbey, London, pp 26–32, 1983.Google Scholar
  165. Tuteur P, Reivick M, Goldberg HI, Cooper ES, West JN, McHenry LC, Cherniach N: Transient responses of cerebral blood flow and ventilation to changes in PaCO2 in normal subjects and patients with cerebrovascular disease. Stroke 7: 584 – 590, 1976.PubMedCrossRefGoogle Scholar
  166. Veall N, Mallet BL:Regional cerebral blood flow determined by 133-Xenon inhalation and external recording: the effect of arterial recirculation. Clin Sci 30: 353 – 369, 1966.PubMedGoogle Scholar
  167. Wada JA, Clarke R, Hamm A: Cerebral hemispheric asimmetry in humans. Arch Neurol 32: 239 – 246, 1975.PubMedCrossRefGoogle Scholar
  168. Wang HS, Busse EW: Correlates of regional cerebral blood flow in elderly community residents. In: Harper AM, Jennett WB, Miller JD, Rowan RO (eds): Blood flow and metabolism in the brain. Edimburgh, Churchill Livingstone, 8.17–8.18, 1975.Google Scholar
  169. Wood F: Theoretical, methodological and statistical implications of the inhalation rCBF technique for the study of brain—behavior relationships. Brain & Language 1 – 8, 1980.Google Scholar
  170. Wood F, Taylor B, Penny R, Stump D: Regional cerebral blood flow response to recognition memory versus semantic classification tasks. Brain & Language 9, 113 – 122, 1980a.CrossRefGoogle Scholar
  171. Wood F, McHenry L, Roman—Campos G, Poser CM: Regional cerebral blood flow response in a patient with remitted global amnesia. Brain & Language 9: 123 – 128, 1980b.CrossRefGoogle Scholar
  172. Wood F, Stump D, McKeehan A, Sheldon S, Proctor J: Patterns of regional cerebral blood flow during attempted reading aloud by stutterers both on and off haloperidol medication: evidence for inadequate Left frontal activation during stuttering. Brain & Language 9: 141 – 144, 1980c.CrossRefGoogle Scholar
  173. Yamaguchi F, Meyer JS„ Sakai F, Yamamoto M: Case reports of three dysphasic patients to illustrate rCBF responses during behavioural activation. Brain and Language 9: 145 – 148, 1980.PubMedCrossRefGoogle Scholar
  174. Yonekura M, Austin G, Poll N, Hayward W: Evaluation of cerebral blood flow in patients with transient ischemic attacks and minor stroke. Surg Neurol 15: 58 – 65, 1981.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • G. Rodriguez
    • 1
  • F. De Carli
    • 1
  • G. Novellone
    • 1
  • S. Marenco
    • 1
  • G. Rosadini
    • 1
  1. 1.Institute of NeurophysiopathologyUniversity of GenoaItaly

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