Estimating Blood Flow by Deconvolution of the Injection of Radioisotope Tracers
Blood flow in vivo can be estimated by a variety of methods. This paper is concerned primarily with techniques associated with the injection of a bolus of a radioisotope tracer, making measurements using an external detector of a bolus being delivered to some target organ, and the amount of the tracer within the target organ. In practice such in vivo methods suffer from many problems, not least, in the choice of an appropriate tracer. The total amount of tracer is difficult to estimate as a result of attenuation and scatter. It is not usually possible to estimate arrival of activity directly to the target organ. The data observed are noisy. This paper is primarily concerned with techniques that may be used to handle such data, with the aim of rendering the use of such methods ‘stable’ if not completely precise. A brief discussion of some other single photon methods of estimating cerebral blood flow is included.
KeywordsSingle Photon Emission Computerize Tomography Cerebral Blood Flow Transit Time Attenuation Correction Input Function
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