Role of Edema in Pathophysiology of Ischemic Injury

  • Igor Klatzo
Part of the Advances in Behavioral Biology book series (ABBI, volume 35)


Although in the past, the role of edema in ischemia has been rather minimized and considered mainly as a feature of necrotic infarct, it becomes increasingly recognized that disturbances of water homeostasis may from the very beginning constitute an integral part in pathophysiology of ischemic brain injury.


Reactive Hyperemia Ischemic Brain Injury Cereb Blood Flow Barrier Opening Ischemic Brain Edema 
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  1. Cahn, R., Martinez, H., Mrsulja, B. B., and Klatzo, I., 1985, Selective vulnerability thresholds in cerebral ischemia, J Cereb Blood Flow Metab, Suppl. 1, 5: S393 - S394.Google Scholar
  2. Hossmann, K.-A., 1979, Cerebral dysfunction related to local and global ischemia of the Brain, in: “Brain Function in Old Age,” F. Hoffmeister and C. Muller, eds., Springer-Verlag, BerlinHeidelberg-New York.Google Scholar
  3. Jacobs, T. P., Shoham, E., Baze, W., Burgard, E., Gunderson C., Hallenbeck, J. M., and Fenerstein, G., 1987, Deteriorating stroke model: Histology, edema, and eicosanoid changes following spinal cord ischemia in rabbits, Stroke, 18: 741–750CrossRefGoogle Scholar
  4. Klatzo, I., Seida, M., Wagner, H. G., and Ting, P., 1986, Features of ischemic brain edema, in: “Pharmacology of Cerebral Ischemia,” J. Krieglstein, ed., Efievier Science Publishers, Amsterdam-New York-Oxford.Google Scholar
  5. Klatzo, I., Seida, M., Tomida, S., Masaoka, H., Vass, K., Wagner, H. G., and Nowak T. S. Jr., 1987, Role of circulatory disturbances in the development of post-ischemic brain edema, in: “Sendai Forum: Membrane Functions and Water and Ion Homeostasis in Ischemic Brain Injury,” K. Kogure, ed., Elsevier Press, in press.Google Scholar
  6. Kuroiwa, T., Ting, P., Martinez, H., and Klatzo, I., 1985, The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion, Acta Neuropathol, 68: 122–129.CrossRefGoogle Scholar
  7. Levy, D. E., Van Uitert, R. L., and Pike, C. L., 1979, Delayed postischemic hypoperfusion: A potentially damaging consequence of stroke, Neurology, 29: 1245–1252.CrossRefGoogle Scholar
  8. Seida, M., Tomia., Wagner,WW H. G., Ting, P., and Klatzo, I., 1987, Role of reactive hyperemia in the dynamics of post-ischemic brain injury, in: “Stroke and Microcirculation,” J. Cervos-Navarro and R. Ferszt, eds., Raven Press, New York.Google Scholar
  9. Suzuki, R., Yamaguchi, T., Kirino T., Orzi, F., and Klatzo I., 1983, The effects of 5-minute ischemia in mongolian gerbils, I, Blood-brain barrier, cerebral blood flow and local glucose utilization changes, Acta Neuropathol, 60: 207–216.CrossRefGoogle Scholar
  10. Suzuki, R., Nitsch, C., Fujiwara, K., and Klatzo, I., 1984, Regional changes in cerebral blood flow and blood-brain barrier permeability during epileptiform seizures and in a cute hypertension in rabbits, J Cereb Blood Flow Metab, 4: 96–102.CrossRefGoogle Scholar
  11. Symon, L., Branston N.M., and Chikovani, O., 1979, Ischemic brain edema following middle cerebral artery occlusion in baboons: Relationship between regional cerebral water content and blood flow at 1 to 2 hours, Stroke, 10: 184–191.CrossRefGoogle Scholar
  12. Ting, P., Masaoka, H., Kuroiwa, T., Wagner, H. G., Fenton, I., and Klatzo, I., 1986, Influence of blood-brain barrier opening to proteins on development of post-ischemic brain injury, Neurol Res, 8: 146–151.Google Scholar
  13. Tomida, S., Nowak, T. S. Jr., Vass, K., Lohr, J. M., and Klatzo, I., 1987, An experimental model for repetitive ischemic attacks in the gerbil: The cumulative effect of repeated ischemic insults, J Cereb Blood Flow Metab, in press.Google Scholar
  14. Vass, K., Tomida, S., Hossmann, K.-A., Nowak, T. S. Jr., and Klatzo, I., Microvascular disturbances and edema formation after repetitive ischemia of gerbil brain, in preparation.Google Scholar
  15. Wagner, H. G., Ting, P., Kito, K., and Yamaguchi, T., 1985, Relationship of ischemic brain edema to electrical impedance and intracranial pressure changes, in: “Brain Edema,” Y. Inaba, I. Klatzo, and M. Spatz, eds., Springer-Verlag, Berlin-Heidelberg-New York-Tokyo.Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Igor Klatzo
    • 1
  1. 1.Laboratory of Neuropathology and Neuroanatomical SciencesNINCDS, National Institutes of HealthBethesdaUSA

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