Glutamine Protects Neuronal Function Against Hypoxia in vitro
Cerebral ischemia/hypoxia is an important pathological condition which is a common and often fatal complication of heart failure and stroke. Our better, though incomplete, understanding of the pathophysiology of this condition, increased the interest in the potential of pharmacological protection of brain tissue against oxygen deprivation. Recently, we analyzed the ventricular drainage fluid from head-injured and acutely hydrocephalic patients as well as lumbar spinal fluid taken during routine myelography for the presence of free amino acids. Among the 13 amino acids that showed a 2–4 fold increase in the impaired patients as compared to the lumbar spinal fluid of normalsl, the increase in glutamine levels to above 1 mM was the most impressive (unpublished results). The present in vitro study was undertaken to determine the role of glutamine, if any, in brain trauma.
KeywordsFree Amino Acid Synaptic Function Population Spike Glutamine Level Hydrocephalic Patient
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