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Glutamine Protects Neuronal Function Against Hypoxia in vitro

  • Avital Schurr
  • David G. Changaris
  • Catherine A. West
  • Benjamin M. Rigor
Part of the Advances in Behavioral Biology book series (ABBI, volume 35)

Abstract

Cerebral ischemia/hypoxia is an important pathological condition which is a common and often fatal complication of heart failure and stroke. Our better, though incomplete, understanding of the pathophysiology of this condition, increased the interest in the potential of pharmacological protection of brain tissue against oxygen deprivation. Recently, we analyzed the ventricular drainage fluid from head-injured and acutely hydrocephalic patients as well as lumbar spinal fluid taken during routine myelography for the presence of free amino acids. Among the 13 amino acids that showed a 2–4 fold increase in the impaired patients as compared to the lumbar spinal fluid of normalsl, the increase in glutamine levels to above 1 mM was the most impressive (unpublished results). The present in vitro study was undertaken to determine the role of glutamine, if any, in brain trauma.

Keywords

Free Amino Acid Synaptic Function Population Spike Glutamine Level Hydrocephalic Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Avital Schurr
    • 2
  • David G. Changaris
    • 1
  • Catherine A. West
    • 2
  • Benjamin M. Rigor
    • 2
  1. 1.Department of Anesthesiology and Department of SurgeryUniversity of Louisville School of MedicineLouisvilleUSA
  2. 2.Division of NeurosurgeryUniversity of Louisville School of MedicineLouisvilleUSA

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