Summary
Adenosine is one of the most potent inhibitory modulators of neuronal activity in the hippocampus. This purine nucleoside acts as an endogenous anticonvulsant and its effects are mediated by specific, high-affinity, A1-type receptors that are concentrated in the selectively vulnerable CA1 area. The regional density of adenosine A1 receptors has been shown to be a critical factor controlling the strength of adenosine inhibition and the number of these receptors is reduced rapidly in CA1 following transient ischemia. The hypothesis is discussed that a postischemic attenuation of adenosine neuromodulation contributes to the destabilization of sensitive CA1 neurons.
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References
T. Kirino, Delayed neuronal death in the gerbil hippocampus following ischemia, Brain Res., 239: 57 (1982).
W. Pulsinelli, J. Brierley and F. Plum, Temporal profile of neuronal damage in a model of transient forebrain ischemia, Ann. Neurol, 11: 491 (1982).
R. Suzuki, T. Yamaguchi, C. Li, and I. Klatzo, The effects of 5 minute ischemia in Mongolian gerbils: II. Changes of spontaneous neuronal activity in cerebral cortex and CA1 sector of hippocampus, Acta Neuropath. 60: 217 (1983).
W. Pulsinelli, Deafferentation of the hippocampus protects CA1 pyramidal. neurons against ischemic injury, Stroke 16: 144 (1985).
R. Simon, J. Swan, T. Griffiths and B. Meldrum, Blockade of N-methyl-Daspartate receptors may protect against ischemic damage in the brain, Science 226: 850 (1984).
J. Hallmayer, K. Hossmann and G. Mies, Low dose of barbiturates for prevention of hippocampal lesions after brief ischemic episodes, Acta Neuropath. (Berlin) 68: 27 (1985).
K. Lee, G. Sancesario, W. Tetzlaff, and G. Kreutzberg, Post-anoxic treatment with anticonvulsants: electrophysiological and anatomical studies of CA1 pyramidal cells, Neuroscience Abs. vol. 12: 869 (1986).
B. Meldrum, T. Griffiths and M. Evans, Hypoxia and neuronal hyper-excitability- A clue to mechanisms of brain protection, in: “Protection of Tissues against Hypoxia” Elsevier Biomed. Press, Amsterdam (1982).
B. Siesjo and T. Wieloch, Cerebral metabolism in ischaemia: neurochemical basis for therapy, Br. J. Anaesth. 57: 47 (1985).
T. Dunwiddie, Endogenously released adenosine regulates excitability in the in vitro hippocampus, Epilepsia 21: 541 (1980).
R. Corradetti, G. Lo Conte, F. Moroni, M. Passani and G. Pepeu, Adenosine decreases aspartate and glutamate release from rat hippocampal slices, Eur. J. Pharmacol. 104: 19 (1984).
D. Madison, A. Fox and R. Tsien, Adenosine reduces an inactivating component of calcium current in hippocampal CA3 neurons, Biophys. J. 51: 30a (1987).
T. Dunwiddie, Interactions between the effects of adenosine and calcium on synaptic responses in rat hippocampus in vitro, J. Physiol. 350: 545 (1984).
T. Dunwiddie and W. Proctor, Mechanisms underlying physiological responses to adenosine in the central nervous system, in: “Topics and Perspectives in Adenosine Research,” E. Gerlach and G. Becker eds. Springer-Verlag, Berlin (1987).
M. Reddington, K. Lee and P. Schubert, An Al-adenosine receptor, characterized by 3H-cyclohexyladenosine binding, mediates the depression of evoked potentials in a rat hippocampal slice preparation, Neurosci. Let. 28: 275 (1982).
G. Siggins and P. Schubert, Adenosine depression of hippocampal neurons in vitro: an intracellular study of dose-dependent actions on synaptic and membrane potentials, Neurosci. Let., 23: 55 (1981).
M. Segal, Intracellular analysis of a postsynaptic action of adenosine in the rat hippocampus, Eur. J. Pharm. 79: 193 (1982).
H. Haas and R. Greene, Adenosine enhances afterhyperpolarization and accommodation in hippocampal pyramidal cells, Pflug Arch 402: 244 (1984)
W. Proctor and T. Dunwiddie, Adenosine inhibits calcium spikes in hippocampal pyramidal neurons in vitro, Neurosci. Let. 35: 197 (1983).
L. Trussel and M. Jackson, Dependence of an adenosine-activated potassium current on a GTP-binding protein in mammalian central neurons, J. Neurosci. 7: 3306 (1987).
K. Lee, P. Schubert and U. Heinemann, The anticonvulsive action of adenosine: a postsynaptic, dendritic action by a possible endogenous anticonvulsant, Brain Res. 321: 160 (1984).
J. Halliwell and C. Scholfield, Somatically recorded Ca-currents in guinea pig hippocampal and olfactory cortex neurones are resistant to adenosine action, Neurosci. Let. 50: 13 (1984).
D. Van Calker, M. Muller, and B. Hamprecht, Adenosine regulates via two different types of receptors the accumulation of cyclic AMP in cultured brain cells. J. Neurochem. 33: 999 (1981).
K. Lee, M. Reddington, P. Schubert and G. Kreutzberg, Regulation of the strength of adenosine modulation in the hippocampus by a differential distribution of the density of Al receptors, Brain Res. 260: 156 (1983).
J. Bernstein, R. Fisher, R. Zaczek and J. Coyle, Dipeptides of glutamate and aspartate may be endogenous neuroexcitants in the rat hippocampal slice, J. Neurosci. 5: 1429 (1985).
H. Hagberg, A. Lehmann, M. Sandberg, B. Nystrom, I. Jacobson and A. Hamberger, Ischemia-induced shift of inhibitory and excitatory amino acids from intra-to extracellular compartments, J. Cereb. Blood Flow and Metab. 5: 413 (1985).
E. Westerberg, D. Monaghan, C. Cotman and T. Wieloch, Excitatory amino acid receptors and ischemic brain damage in the rat, Neurosci. Let. 73: 119 (1987).
K. Lee, W. Tetzlaff and G. Kreutzberg, Rapid down regulation of hippocampal adenosine receptors following brief anoxia, Brain Res. 380: 155 (1986).
K. Rudolphi, M. Keil and H. Hinze, Effect of theophylline on ischemically induced hippocampal damage in Mongolian gerbils: A behavioral and histopathological study, J Cereb Blood Flow and Metab 7: 74 (1987)
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© 1988 Plenum Press, New York
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Lee, K.S., Kreutzberg, G.W. (1988). Adenosine Neuromodulation of Selectively Vulnerable CA1 Neurons. In: Somjen, G. (eds) Mechanisms of Cerebral Hypoxia and Stroke. Advances in Behavioral Biology, vol 35. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5562-5_46
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DOI: https://doi.org/10.1007/978-1-4684-5562-5_46
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