Prophylaxis and Therapy of Hypoxic and Ischemic Brain: Effects of Monosialoganglioside GM1

  • C. Aldinio
  • M. S. Seren
  • G. Toffano
  • A. Leon
Part of the Advances in Behavioral Biology book series (ABBI, volume 35)


Among novel pharmacological strategies aiming at reducing deficits or enhancing repair following CNS injury, the application of monosialoganglioside GM1 is today of considerable interest. Several evidences indicate that exogenous gangliosides appear to be an effective pharmacological approach in the treatment of various types of brain damage, not only traumatic or toxic, but also following experimentally-induced cerebral ischemia. Ganglioside treatments reduce the extent of secondary-induced neuronal degeneration at early post-lesion stages and improve long-term outcome following CNS insults. Evidences supporting these ganglioside effects and their potential therapeutical use in the acute phase following cerebral ischemia will be discussed in the present chapter.


Cerebral Ischemia Basal Forebrain Transient Cerebral Ischemia Brain Insult Behavioral Asymmetry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • C. Aldinio
    • 1
  • M. S. Seren
    • 1
  • G. Toffano
    • 1
  • A. Leon
    • 1
  1. 1.Fidia Research LaboratoriesAbano TermeItaly

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