Improvement of Postischemic Cell Damage and Energy Metabolism in the Rat by Flunarizine and Emopamil
In previous studies the calcium entry blocker flunarizine has been demonstrated to reduce hippocampal cell damage following forebrain ischemia in the rat (1–3). The purpose of the present investigation was to evaluate whether the phenylalkylamine derivative emopamil also could prevent neuronal cell loss following ischemia. A variety of calcium entry blockers including flunarizine and emopamil has on the other hand been shown to faster restore postischemic high-energy phosphate levels in the isolated perfused rat brain (4). The present study therefore aimed at evaluating whether cellular protection by calcium entry blockers might be associated with an improved energy metabolism during early recovery.
KeywordsIschemia Neurol Flunarizine Emopamil
- Deshpande, J.K., Wieloch, T. (1985) Neurol. Res. 7:27–29Google Scholar