Improvement of Postischemic Cell Damage and Energy Metabolism in the Rat by Flunarizine and Emopamil

  • D. Sauer
  • G. W. Bielenberg
  • J. Nuglisch
  • T. Beck
  • H. D. Mennel
  • C. Rossberg
  • J. Krieglstein
Part of the Advances in Behavioral Biology book series (ABBI, volume 35)

Abstract

In previous studies the calcium entry blocker flunarizine has been demonstrated to reduce hippocampal cell damage following forebrain ischemia in the rat (1–3). The purpose of the present investigation was to evaluate whether the phenylalkylamine derivative emopamil also could prevent neuronal cell loss following ischemia. A variety of calcium entry blockers including flunarizine and emopamil has on the other hand been shown to faster restore postischemic high-energy phosphate levels in the isolated perfused rat brain (4). The present study therefore aimed at evaluating whether cellular protection by calcium entry blockers might be associated with an improved energy metabolism during early recovery.

Keywords

Ischemia Neurol Flunarizine Emopamil 

References

  1. 1.
    Deshpande, J.K., Wieloch, T. (1985) Anesthesiology 64: 215–224.CrossRefGoogle Scholar
  2. Deshpande, J.K., Wieloch, T. (1985) Neurol. Res. 7:27–29Google Scholar
  3. Van Reempts, J., Haseldonckx, M., Van Deuren, B., Wouters, L., Borgers, M. (1986) Drug Develop. Res. 8:387–395CrossRefGoogle Scholar
  4. 4.
    Krieglstein, J., Weber, J. (1986) In: I. Longmuir (ed.) Oxygen Transport to Tissue VIII. Plenum Press, New York, pp. 243–251.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • D. Sauer
    • 1
  • G. W. Bielenberg
    • 1
  • J. Nuglisch
    • 1
  • T. Beck
    • 1
  • H. D. Mennel
    • 2
  • C. Rossberg
    • 2
  • J. Krieglstein
    • 1
  1. 1.Institut für Pharmakologie und ToxikologieMarburgGermany
  2. 2.Medizinisches Zentrum für PathologieAbteilung NeuropathologieBaldingerstrGermany

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