Dopamine and the Susceptibility of Striatal Neurons to Ischemia
Neuropathologists have long noted that certain brain regions and specific neuronal types are especially vulnerable to an ischemic insult (2). With the advent of small animal models of ischemia, it has been possible to perform studies of selective vulnerability under controlled conditions. These studies have shown that transient ischemia in rats leads to selective neuronal damage in discrete brain regions such as the CA1 pyramidal cells in the hippocampus and the small-to-medium sized neurons in the striatum (7,24). It has been suggested that excessive release of excitatory neurotransmitters and increased synaptic activity might play a major role in the mediation of postischemic neuronal cell death in selectively vulnerable brain regions (32). However, most of the previous work has focused on the release of glutamate (Glu) and the vulnerability of the hippocampus to ischemia (25,26,27). The striatum, a region highly vulnerable to ischemia, is richly innervated by the nigrostriatal dopaminergic system. This raises the possibility that dopamine (DA) might be involved in ischemic striatal injury.
KeywordsStriatal Neuron Ischemic Cell Transient Forebrain Ischemia Local Cerebral Blood Flow Dorsolateral Striatum
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