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Magnesium Inhibits Ischemia Induced Calcium Accumulation in Hilar Neurones: Possible Effect of Nmda-Receptor

  • Helene Benveniste
  • Nils Henrik Diemer
Part of the Advances in Behavioral Biology book series (ABBI, volume 35)

Abstract

Ischemic damage in the hippocampus is characterized by a selective vulnerability. Seventy-two hours following ischemia both irreversible morphological changes and excessive calcium accumulation can be demonstrated in CA-1 pyramidal cells (delayed neurone death). However, hilar neurons show rapid ischemic changes. Six hours following ischemia morphological damage can be demonstrated in hilar neurons, and recently we found excessive accumulation of calcium, 45 min following ischemia. Much evidence has accumulated, that Ca2+ plays a pivotal role in the pathogenesis of ischemic brain damage. Part of the ischemia induced calcium influx takes place via the N-methyl-D-aspartate (NMDA) receptor coupled, magnesium gated calcium conductance.

Keywords

Ischemic Damage Excessive Accumulation Dorsal Hippocampus Microdialysis Probe Calcium Accumulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Helene Benveniste
    • 1
  • Nils Henrik Diemer
    • 1
  1. 1.Institute of NeuropathologyUniversity of CopenhagenDenmark

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